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시냅스 뇌질환 연구단
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Early Correction of N-Methyl-D-Aspartate Receptor Function Improves Autistic-like Social Behaviors in Adult Shank2−/− Mice

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Title
Early Correction of N-Methyl-D-Aspartate Receptor Function Improves Autistic-like Social Behaviors in Adult Shank2−/− Mice
Author(s)
Changuk Chung; Seungmin Ha; Hyojin Kang; Jiseok Lee; Seung Min Um; Haidun Yan; Ye-Eun Yoo; Taesun Yoo; Hwajin Jung; Dongwon Lee; Eunee Lee; Seungjoon Lee; Jihye Kim; Ryunhee Kim; Yonghan Kwon; Woohyun Kim; Hyosang Kim; Lara Duffney; Doyoun Kim; Won Mah; Hyejung Won; Seojung Mo; Jin Yong Kim; Chae-Seok Lim; Bong-Kiun Kaang; Tobias M. Boeckers; Yeonseung Chung; Hyun Kim; Yong-hui Jiang; Eunjoon Kim
Publication Date
2019-04
Journal
BIOLOGICAL PSYCHIATRY, v.85, no.7, pp.534 - 543
Publisher
ELSEVIER SCIENCE INC
Abstract
BACKGROUND: Autism spectrum disorder involves neurodevelopmental dysregulations that lead to visible symptoms at early stages of life. Many autism spectrum disorder–related mechanisms suggested by animal studies are supported by demonstrated improvement in autistic-like phenotypes in adult animals following experimental reversal of dysregulated mechanisms. However, whether such mechanisms also act at earlier stages to cause autistic-like phenotypes is unclear. METHODS: We used Shank22/2 mice carrying a mutation identified in human autism spectrum disorder (exons 6 and 7 deletion) and combined electrophysiological and behavioral analyses to see whether early pathophysiology at pup stages is different from late pathophysiology at juvenile and adult stages and whether correcting early pathophysiology can normalize late pathophysiology and abnormal behaviors in juvenile and adult mice. RESULTS: Early correction of a dysregulated mechanism in young mice prevents manifestation of autistic-like social behaviors in adult mice. Shank22/2 mice, known to display N-methyl-D-aspartate receptor (NMDAR) hypofunction and autistic-like behaviors at postweaning stages after postnatal day 21 (P21), show the opposite synaptic phenotype—NMDAR hyperfunction—at an earlier preweaning stage (wP14). Moreover, this NMDAR hyperfunction at P14 rapidly shifts to NMDAR hypofunction after weaning (wP24). Chronic suppression of the early NMDAR hyperfunction by the NMDAR antagonist memantine (P7–P21) prevents NMDAR hypofunction and autistic-like social behaviors from manifesting at later stages (wP28 and P56). CONCLUSIONS: Early NMDAR hyperfunction leads to late NMDAR hypofunction and autistic-like social behaviors in Shank22/2 mice, and early correction of NMDAR dysfunction has the long-lasting effect of preventing autistic-like social behaviors from developing at later stages. c. 2018 Society of Biological Psychiatry.
URI
https://pr.ibs.re.kr/handle/8788114/5652
ISSN
0006-3223
Appears in Collections:
Center for Synaptic Brain Dysfunctions(시냅스 뇌질환 연구단) > Journal Papers (저널논문)
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