BROWSE

Related Scientist

cchf's photo.

cchf
분자활성촉매반응연구단
more info

ITEM VIEW & DOWNLOAD

Discovery of fluorescent 3-heteroarylcoumarin derivatives as novel inhibitors of anaplastic lymphoma kinase

DC Field Value Language
dc.contributor.authorShinmee Mah-
dc.contributor.authorJaebong Jang-
dc.contributor.authorDaesun Song-
dc.contributor.authorYongje Shin-
dc.contributor.authorMuhammad Latif-
dc.contributor.authorYongwon Jung-
dc.contributor.authorSungwoo Hong-
dc.date.available2019-02-20T08:16:00Z-
dc.date.created2019-01-28-
dc.date.issued2019-01-
dc.identifier.issn1477-0520-
dc.identifier.urihttps://pr.ibs.re.kr/handle/8788114/5602-
dc.description.abstractAltered expression or hyperactivation of anaplastic lymphoma kinase (ALK), as a consequence of translocations or point mutations, is one of the main oncogenic drivers in non-small cell lung cancer. Using structure-based design and in vitro enzyme assays, we identified 3-heteroarylcoumarin as a new template for the development of novel fluorescent ALK inhibitors. Molecular simulation provided structural insights for the design of 3-heteroarylcoumarin derivatives, which were easily prepared through efficient synthetic approaches including direct C-H cross coupling. Importantly, these coumarin-based ALK inhibitors can be tracked using microscopy techniques: we illustrated the use of the most potent compound in this series, 5a, (ALK/IC50 = 0.51 M, (emi) = 500 nm, phi(F) = 0.29) to monitor its subcellular distribution pattern by confocal fluorescence microscopy © The Royal Society of Chemistry 2019-
dc.description.uri1-
dc.language영어-
dc.publisherROYAL SOC CHEMISTRY-
dc.titleDiscovery of fluorescent 3-heteroarylcoumarin derivatives as novel inhibitors of anaplastic lymphoma kinase-
dc.typeArticle-
dc.type.rimsART-
dc.identifier.wosid000454251100022-
dc.identifier.scopusid2-s2.0-85058839879-
dc.identifier.rimsid66735-
dc.contributor.affiliatedAuthorShinmee Mah-
dc.contributor.affiliatedAuthorJaebong Jang-
dc.contributor.affiliatedAuthorYongje Shin-
dc.contributor.affiliatedAuthorMuhammad Latif-
dc.contributor.affiliatedAuthorSungwoo Hong-
dc.identifier.doi10.1039/c8ob02874e-
dc.identifier.bibliographicCitationORGANIC & BIOMOLECULAR CHEMISTRY, v.17, no.1, pp.186 - 194-
dc.citation.titleORGANIC & BIOMOLECULAR CHEMISTRY-
dc.citation.volume17-
dc.citation.number1-
dc.citation.startPage186-
dc.citation.endPage194-
dc.description.journalClass1-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
Appears in Collections:
Center for Catalytic Hydrocarbon Functionalizations(분자활성 촉매반응 연구단) > 1. Journal Papers (저널논문)
Files in This Item:
c8ob02874e.pdfDownload

qrcode

  • facebook

    twitter

  • Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse