Metal-free photocatalytic trifluoromethylative pyridylation of unactivated alkenes

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Title
Metal-free photocatalytic trifluoromethylative pyridylation of unactivated alkenes
Author(s)
Yu-Tao He; Dahye Kang; Inwon Kim; Sungwoo Hong
Publication Date
2018-11
Journal
GREEN CHEMISTRY, v.20, no.22, pp.5209 - 5214
Publisher
ROYAL SOC CHEMISTRY
Abstract
An efficient, transition metal-free trifluoromethylative pyridylation of unactivated alkenes was achieved by visible-light-induced photoredox catalysis employing CF3SO2Na and a pyridinium salt in the presence of eosin Y as a photoredox catalyst. The overall process is thought to occur by the selective addition of an electrophilic CF3 radical to the alkene substrate to provide an alkyl radical intermediate, which subsequently engages in an addition to the pyridinium salt. This three-component photocatalytic strategy circumvents traditional multistep procedures and readily affords synthetically and biologically important trifluoromethyl- and pyridyl-containing frameworks. © 2018 The Royal Society of Chemistry
URI
https://pr.ibs.re.kr/handle/8788114/5414
ISSN
1463-9262
Appears in Collections:
Center for Catalytic Hydrocarbon Functionalizations(분자활성 촉매반응 연구단) > Journal Papers (저널논문)
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