BROWSE

Related Scientist

Researcher

정민환
시냅스 뇌질환 연구단
more info

Remembering rewarding futures: a simulation-selection model of the hippocampus

Cited 0 time in webofscience Cited 0 time in scopus
23 Viewed 9 Downloaded
Title
Remembering rewarding futures: a simulation-selection model of the hippocampus
Author(s)
Min Whan Jung; Hyunjung Lee; Yeongseok Jeong; Jong Won Lee; Inah Lee
Publication Date
2018-12
Journal
HIPPOCAMPUS, v.28, no.12, pp.913 - 930
Publisher
WILEY-BLACKWELL
Abstract
Despite tremendous progress, the neural neural neuralneural circuitcircuit circuitcircuit dynamicsdynamicsdynamicsdynamicsdynamics dynamicsdynamics underlying hippocampal mnemonic processing remain poorly understood. We propose a new model for hippocampal function—the simulation-selection model—based on recent experimental findings and neuroecological considerations. Under this model, the mammalian hippocampus evolved to simulate and evaluate arbitrary navigation sequences. Specifically, we suggest that CA3 simulates unexperienced navigation sequences in addition to remembering experienced ones, and CA1 selects from among these CA3-generated sequences, reinforcing those that are likely to maximize reward during offline idling states. High-value sequences reinforced in CA1 may allow flexible navigation toward a potential rewarding location during subsequent navigation. We argue that the simulation-selection functions of the hippocampus have evolved in mammals mostly because of the unique navigational needs of land mammals. Our model may account for why the mammalian hippocampus has evolved not only to remember, but also to imagine episodes, and how this might be implemented in its neural circuits. © 2018 The Authors. Hippocampus published by Wiley Periodicals, Inc.
URI
https://pr.ibs.re.kr/handle/8788114/5372
ISSN
1050-9631
Appears in Collections:
Center for Synaptic Brain Dysfunctions(시냅스 뇌질환 연구단) > Journal Papers (저널논문)
Files in This Item:
Jung_et_al-2018-Hippocampus.pdfDownload

qrcode

  • facebook

    twitter

  • Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse