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뇌과학이미징연구단
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Intracellularly Activatable Nanovasodilators To Enhance Passive Cancer Targeting Regime

DC Field Value Language
dc.contributor.authorV. G.Deepagan-
dc.contributor.authorHyewon Ko-
dc.contributor.authorSeunglee Kwon-
dc.contributor.authorN. Vijayakameswara Rao-
dc.contributor.authorSnag Kyoon Kim-
dc.contributor.authorWooram Um-
dc.contributor.authorSohee Lee-
dc.contributor.authorJuwoong Min-
dc.contributor.authorJeongjin Lee-
dc.contributor.authorKi Young Choi-
dc.contributor.authorSol Shin-
dc.contributor.authorMinah Suh-
dc.contributor.authorJae Hyung Park-
dc.date.available2019-01-03T05:34:21Z-
dc.date.created2018-06-12-
dc.date.issued2018-04-
dc.identifier.issn1530-6984-
dc.identifier.urihttps://pr.ibs.re.kr/handle/8788114/5291-
dc.description.abstractConventional cancer targeting with nanoparticles has been based on the assumed enhanced permeability and retention (EPR) effect. The data obtained in clinical trials to date, however, have rarely supported the presence of such an effect. To address this challenge, we formulated intracellular nitric oxide-generating nanoparticles (NO-NPs) for the tumor site-specific delivery of NO, a well-known vasodilator, with the intention of boosting EPR. These nanoparticles are self-assembled under aqueous conditions from amphiphilic copolymers of poly(ethylene glycol) and nitrated dextran, which possesses inherent NO release properties in the reductive environment of cancer cells. After systemic administration of the NO-NPs, we quantitatively assessed and visualized increased tumor blood flow as well as enhanced vascular permeability than could be achieved without NO. Additionally, we prepared doxorubicin (DOX)-encapsulated NO-NPs and demonstrated consequential improvement in therapeutic efficacy over the control groups with considerably improved DOX intratumoral accumulation. Overall, this proof of concept study implies a high potency of the NO-NPs as an EPR enhancer to achieve better clinical outcomes © 2018 American Chemical Society-
dc.description.uri1-
dc.language영어-
dc.publisherAMER CHEMICAL SOC-
dc.subjectNitric oxide-
dc.subjectnitrated polysaccharide-
dc.subjectvasodilation-
dc.subjectenhanced permeability and retention effect-
dc.subjectdrug delivery-
dc.titleIntracellularly Activatable Nanovasodilators To Enhance Passive Cancer Targeting Regime-
dc.typeArticle-
dc.type.rimsART-
dc.identifier.wosid000430155900062-
dc.identifier.scopusid2-s2.0-85045189574-
dc.identifier.rimsid63563-
dc.contributor.affiliatedAuthorSohee Lee-
dc.contributor.affiliatedAuthorJuwoong Min-
dc.contributor.affiliatedAuthorMinah Suh-
dc.identifier.doi10.1021/acs.nanolett.8b00495-
dc.identifier.bibliographicCitationNANO LETTERS, v.18, no.4, pp.2637 - 2644-
dc.citation.titleNANO LETTERS-
dc.citation.volume18-
dc.citation.number4-
dc.citation.startPage2637-
dc.citation.endPage2644-
dc.description.journalClass1-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.subject.keywordPlusNITRIC-OXIDE-
dc.subject.keywordPlusDRUG-DELIVERY-
dc.subject.keywordPlusSOLID TUMORS-
dc.subject.keywordPlusIN-VIVO-
dc.subject.keywordPlusPERMEABILITY-
dc.subject.keywordPlusRETENTION-
dc.subject.keywordPlusCELLS-
dc.subject.keywordPlusNANOPARTICLES-
dc.subject.keywordPlusNITROGLYCERIN-
dc.subject.keywordPlusMETABOLISM-
dc.subject.keywordAuthorNitric oxide-
dc.subject.keywordAuthornitrated polysaccharide-
dc.subject.keywordAuthorvasodilation-
dc.subject.keywordAuthorenhanced permeability and retention effect-
dc.subject.keywordAuthordrug delivery-
Appears in Collections:
Center for Neuroscience Imaging Research (뇌과학 이미징 연구단) > 1. Journal Papers (저널논문)
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