Distinct dynamics of striatal and prefrontal neural activity during temporal discrimination

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Title
Distinct dynamics of striatal and prefrontal neural activity during temporal discrimination
Author(s)
Jieun Kim; Dohoung Kim; Min Whan Jung
Publication Date
2018-08
Journal
FRONTIERS IN INTEGRATIVE NEUROSCIENCE, v.12, no., pp.34 -
Publisher
FRONTIERS MEDIA SAFrontiers Research Foundation
Abstract
The frontal cortex-basal ganglia circuit plays an important role in interval timing. We examined neuronal discharges in the dorsomedial and dorsolateral striatum (DMS and DLS) in rats performing a temporal categorization task and compared them with previously recorded neuronal activity in the medial prefrontal cortex (mPFC). All three structures conveyed significant temporal information, but striatal neurons seldom showed the prolonged, full-interval spanning ramping activity frequently observed in the mPFC. Instead, the majority fired briefly during sample intervals. Also, the precision of neural time decoding became progressively worse with increasing time duration in the mPFC, but not in the striatum. With the caveat that mPFC and striatal units were recorded from different animals, our results suggest that the striatum and mPFC convey temporal information via distinct neural processes. (c) 2018 Kim, Kim and Jung
URI
https://pr.ibs.re.kr/handle/8788114/5212
ISSN
1662-5145
Appears in Collections:
Center for Synaptic Brain Dysfunctions(시냅스 뇌질환 연구단) > Journal Papers (저널논문)
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