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Drug Repositioning to Alleviate Systemic Inflammatory Response Syndrome Caused by Gram-Negative Bacterial Outer Membrane Vesicles

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dc.contributor.authorJi Hyun Kim-
dc.contributor.authorJaewook Lee-
dc.contributor.authorKyong-Su Park-
dc.contributor.authorSung-Wook Hong-
dc.contributor.authorYong Song Gho-
dc.date.available2018-12-13T10:45:59Z-
dc.date.created2018-08-17-
dc.date.issued2018-07-
dc.identifier.issn2192-2640-
dc.identifier.urihttps://pr.ibs.re.kr/handle/8788114/4958-
dc.description.abstractSepsis is characterized by systemic inflammatory response syndrome (SIRS) accompanied with infection. Gram-negative bacteria can evoke sepsis by activating the host immune system, such as the release of IL-6 and TNF-alpha, through their virulence factors. Outer membrane vesicles (OMVs), nanosized bilayered proteolipids derived from Gram-negative bacteria, harbor various virulence factors and are shown to induce SIRS. Here, drugs are repositioned to alleviate SIRS caused by Gram-negative bacterial OMVs. Using novel OMV-based drug screening systems, a total of 178 commercially available drugs are primarily screened, and a total of 18 repositioned drug candidates are found to effectively block IL-6 and TNF-alpha production from OMV-stimulated macrophages. After excluding the compounds which are previously known to intervene sepsis or which show cytotoxicity to macrophages, the compounds which show dose-dependency in inhibiting the release of IL-6 and TNF-alpha by the OMV-stimulated macrophages in vitro and which reduce OMV-induced SIRS in vivo are selected. Salbutamol, a beta 2 adrenergic receptor agonist, is selected as a novel candidate to alleviate OMV-induced SIRS. This study sheds light on using Gram-negative bacterial OMVs in exploring novel candidate compounds to alleviate inflammatory diseases including sepsis-
dc.language영어-
dc.publisherWILEY-
dc.subjectdrug repositioning-
dc.subjectextracellular vesicles-
dc.subjectouter membrane vesicles-
dc.subjectsepsis-
dc.subjectsystemic inflammatory response syndrome-
dc.titleDrug Repositioning to Alleviate Systemic Inflammatory Response Syndrome Caused by Gram-Negative Bacterial Outer Membrane Vesicles-
dc.typeArticle-
dc.type.rimsART-
dc.identifier.wosid000438193900010-
dc.identifier.scopusid2-s2.0-85045757919-
dc.identifier.rimsid64378-
dc.contributor.affiliatedAuthorSung-Wook Hong-
dc.identifier.doi10.1002/adhm.201701476-
dc.identifier.bibliographicCitationADVANCED HEALTHCARE MATERIALS, v.7, no.13, pp.1701476(1) - 1701476(6)-
dc.relation.isPartOfADVANCED HEALTHCARE MATERIALS-
dc.citation.titleADVANCED HEALTHCARE MATERIALS-
dc.citation.volume7-
dc.citation.number13-
dc.citation.startPage1701476(1)-
dc.citation.endPage1701476(6)-
dc.embargo.liftdate9999-12-31-
dc.embargo.terms9999-12-31-
dc.description.journalClass1-
dc.description.journalClass1-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalWebOfScienceCategoryEngineering, Biomedical-
dc.relation.journalWebOfScienceCategoryNanoscience & Nanotechnology-
dc.relation.journalWebOfScienceCategoryMaterials Science, Biomaterials-
dc.subject.keywordPlusSEPTIC SHOCK-
dc.subject.keywordPlusPSEUDOMONAS-AERUGINOSA-
dc.subject.keywordPlusSEVERE SEPSIS-
dc.subject.keywordPlusLETHAL BACTEREMIA-
dc.subject.keywordPlusLIPOPOLYSACCHARIDE-
dc.subject.keywordPlusINTERLEUKIN-1-BETA-
dc.subject.keywordPlusBIOGENESIS-
dc.subject.keywordPlusANTIBODIES-
dc.subject.keywordPlusMANAGEMENT-
dc.subject.keywordPlusCYTOKINES-
dc.subject.keywordAuthordrug repositioning-
dc.subject.keywordAuthorextracellular vesicles-
dc.subject.keywordAuthorouter membrane vesicles-
dc.subject.keywordAuthorsepsis-
dc.subject.keywordAuthorsystemic inflammatory response syndrome-
Appears in Collections:
Academy of Immunology and Microbiology(면역 미생물 공생 연구단) > 1. Journal Papers (저널논문)
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