Drug Repositioning to Alleviate Systemic Inflammatory Response Syndrome Caused by Gram-Negative Bacterial Outer Membrane Vesicles
DC Field | Value | Language |
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dc.contributor.author | Ji Hyun Kim | - |
dc.contributor.author | Jaewook Lee | - |
dc.contributor.author | Kyong-Su Park | - |
dc.contributor.author | Sung-Wook Hong | - |
dc.contributor.author | Yong Song Gho | - |
dc.date.available | 2018-12-13T10:45:59Z | - |
dc.date.created | 2018-08-17 | - |
dc.date.issued | 2018-07 | - |
dc.identifier.issn | 2192-2640 | - |
dc.identifier.uri | https://pr.ibs.re.kr/handle/8788114/4958 | - |
dc.description.abstract | Sepsis is characterized by systemic inflammatory response syndrome (SIRS) accompanied with infection. Gram-negative bacteria can evoke sepsis by activating the host immune system, such as the release of IL-6 and TNF-alpha, through their virulence factors. Outer membrane vesicles (OMVs), nanosized bilayered proteolipids derived from Gram-negative bacteria, harbor various virulence factors and are shown to induce SIRS. Here, drugs are repositioned to alleviate SIRS caused by Gram-negative bacterial OMVs. Using novel OMV-based drug screening systems, a total of 178 commercially available drugs are primarily screened, and a total of 18 repositioned drug candidates are found to effectively block IL-6 and TNF-alpha production from OMV-stimulated macrophages. After excluding the compounds which are previously known to intervene sepsis or which show cytotoxicity to macrophages, the compounds which show dose-dependency in inhibiting the release of IL-6 and TNF-alpha by the OMV-stimulated macrophages in vitro and which reduce OMV-induced SIRS in vivo are selected. Salbutamol, a beta 2 adrenergic receptor agonist, is selected as a novel candidate to alleviate OMV-induced SIRS. This study sheds light on using Gram-negative bacterial OMVs in exploring novel candidate compounds to alleviate inflammatory diseases including sepsis | - |
dc.language | 영어 | - |
dc.publisher | WILEY | - |
dc.subject | drug repositioning | - |
dc.subject | extracellular vesicles | - |
dc.subject | outer membrane vesicles | - |
dc.subject | sepsis | - |
dc.subject | systemic inflammatory response syndrome | - |
dc.title | Drug Repositioning to Alleviate Systemic Inflammatory Response Syndrome Caused by Gram-Negative Bacterial Outer Membrane Vesicles | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.identifier.wosid | 000438193900010 | - |
dc.identifier.scopusid | 2-s2.0-85045757919 | - |
dc.identifier.rimsid | 64378 | - |
dc.contributor.affiliatedAuthor | Sung-Wook Hong | - |
dc.identifier.doi | 10.1002/adhm.201701476 | - |
dc.identifier.bibliographicCitation | ADVANCED HEALTHCARE MATERIALS, v.7, no.13, pp.1701476(1) - 1701476(6) | - |
dc.relation.isPartOf | ADVANCED HEALTHCARE MATERIALS | - |
dc.citation.title | ADVANCED HEALTHCARE MATERIALS | - |
dc.citation.volume | 7 | - |
dc.citation.number | 13 | - |
dc.citation.startPage | 1701476(1) | - |
dc.citation.endPage | 1701476(6) | - |
dc.embargo.liftdate | 9999-12-31 | - |
dc.embargo.terms | 9999-12-31 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalWebOfScienceCategory | Engineering, Biomedical | - |
dc.relation.journalWebOfScienceCategory | Nanoscience & Nanotechnology | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Biomaterials | - |
dc.subject.keywordPlus | SEPTIC SHOCK | - |
dc.subject.keywordPlus | PSEUDOMONAS-AERUGINOSA | - |
dc.subject.keywordPlus | SEVERE SEPSIS | - |
dc.subject.keywordPlus | LETHAL BACTEREMIA | - |
dc.subject.keywordPlus | LIPOPOLYSACCHARIDE | - |
dc.subject.keywordPlus | INTERLEUKIN-1-BETA | - |
dc.subject.keywordPlus | BIOGENESIS | - |
dc.subject.keywordPlus | ANTIBODIES | - |
dc.subject.keywordPlus | MANAGEMENT | - |
dc.subject.keywordPlus | CYTOKINES | - |
dc.subject.keywordAuthor | drug repositioning | - |
dc.subject.keywordAuthor | extracellular vesicles | - |
dc.subject.keywordAuthor | outer membrane vesicles | - |
dc.subject.keywordAuthor | sepsis | - |
dc.subject.keywordAuthor | systemic inflammatory response syndrome | - |