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Intravital imaging of mouse bone marrow: Hemodynamics and vascular permeability

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Title
Intravital imaging of mouse bone marrow: Hemodynamics and vascular permeability
Author(s)
Yookyung Jung; Joel A. Spencer; Anthony P. Raphael; Juwell W. Wu; Clemens Alt; Judith R. Runnels; Briaira Geiger; Charles P. Lin
Publication Date
2018-05
Journal
Methods in molecular biology (Clifton, N.J.), v.1763, no., pp.11 - 22
Publisher
Humana Press, Inc.
Abstract
The bone marrow is a unique microenvironment where blood cells are produced and released into the circulation. At the top of the blood cell lineage are the hematopoietic stem cells (HSC), which are thought to reside in close association with the bone marrow vascular endothelial cells (Morrison and Scadden, Nature 505:327–334, 2014). Recent efforts at characterizing the HSC niche have prompted us to make close examinations of two distinct types of blood vessel in the bone marrow, the arteriolar vessels originating from arteries and sinusoidal vessels connected to veins. We found the two vessel types to exhibit different vascular permeabilites, hemodynamics, cell trafficking behaviors, and oxygen content (Itkin et al., Nature 532:323–328, 2016; Spencer et al., Nature 508:269–273, 2014). Here, we describe a method to quantitatively measure the permeability and hemodynamics of arterioles and sinusoids in murine calvarial bone marrow using intravital microscopy. © 2018, Springer Science+Business Media, LLC
URI
https://pr.ibs.re.kr/handle/8788114/4536
ISSN
1064-3745
Appears in Collections:
Center for Molecular Spectroscopy and Dynamics(분자 분광학 및 동력학 연구단) > Journal Papers (저널논문)
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