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Koh, Gou Young
혈관 연구단
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Myocardial Angiopoietin-1 Controls Atrial Chamber Morphogenesis by Spatiotemporal Degradation of Cardiac Jelly

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dc.contributor.authorKyun Hoo Kim-
dc.contributor.authorNakaoka Y.-
dc.contributor.authorAugustin H.G.-
dc.contributor.authorGou Young Koh-
dc.date.available2018-07-18T02:03:11Z-
dc.date.created2018-06-26ko
dc.date.issued2018-05-
dc.identifier.issn2211-1247-
dc.identifier.urihttps://pr.ibs.re.kr/handle/8788114/4527-
dc.description.abstractThe four-chamber structure of the mammalian heart is established during embryonic development. While key regulators for ventricular development are well studied, regulatory mechanisms for atrial chamber morphogenesis remain poorly understood. Here, we found that angiopoietin-1 (Angpt1), a vascular maturation factor, is highly and specifically expressed in atrial myocardium during heart development. Loss of myocardial Angpt1 in mouse embryo led to severe impairment in atrial chamber morphogenesis. We revealed that Angpt1 deficiency results in excessive deposition of cardiac jelly, which disturbs regulation of myocardial growth, thereby impairing maturation of atrial chambers. Mechanistically, myocardial Angpt1 activates endocardial Tie2 and positively regulates expression of ADAMTS proteases, which is crucial for proper degradation of cardiac jelly. Accordingly, loss of Tie2 also impairs ADAMTS-mediated degradation of cardiac jelly in atrium. Collectively, myocardial Angpt1/endocardial Tie2 signaling in atrium promotes spatiotemporal degradation of cardiac jelly during early cardiac development and is therefore indispensable for atrial chamber morphogenesis. Kim et al. demonstrate that myocardium-derived Angpt1 is indispensable for atrial chamber morphogenesis. Myocardial Angpt1 activates endocardial Tie2 signaling and positively regulates ADAMTS-dependent degradation of cardiac jelly. Proper distribution of cardiac jelly is critical for the regulation of myocardial growth and chamber morphogenesis in the atrium. © 2018 The Author(s-
dc.description.uri1-
dc.language영어-
dc.publisherCELL PRESS-
dc.titleMyocardial Angiopoietin-1 Controls Atrial Chamber Morphogenesis by Spatiotemporal Degradation of Cardiac Jelly-
dc.typeArticle-
dc.type.rimsART-
dc.identifier.wosid000433052200022-
dc.identifier.scopusid2-s2.0-85047190145-
dc.identifier.rimsid63874ko
dc.date.tcdate2018-10-01-
dc.contributor.affiliatedAuthorGou Young Koh-
dc.identifier.doi10.1016/j.celrep.2018.04.080-
dc.identifier.bibliographicCitationCELL REPORTS, v.23, no.8, pp.2455 - 2466-
dc.citation.titleCELL REPORTS-
dc.citation.volume23-
dc.citation.number8-
dc.citation.startPage2455-
dc.citation.endPage2466-
dc.date.scptcdate2018-10-01-
dc.description.scptc0-
dc.description.journalClass1-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
Appears in Collections:
Center for Vascular Research(혈관 연구단) > 1. Journal Papers (저널논문)
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