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인지및사회성연구단
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Spatiotemporal Control of TGF-β Signaling with Light

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dc.contributor.authorYuchao Li-
dc.contributor.authorMinji Lee-
dc.contributor.authorNury, Kim-
dc.contributor.authorGuoyu Wu-
dc.contributor.authorDifan Deng-
dc.contributor.authorJin Man Kim-
dc.contributor.authorXuedong Liu-
dc.contributor.authorWon Do Heo-
dc.contributor.authorZhike Zi-
dc.date.available2018-03-05T01:03:37Z-
dc.date.created2018-01-29-
dc.date.issued2018-02-
dc.identifier.issn2161-5063-
dc.identifier.urihttps://pr.ibs.re.kr/handle/8788114/4376-
dc.description.abstractCells employ signaling pathways to make decisions in response to changes in their immediate environment. Transforming growth factor beta (TGF-β) is an important growth factor that regulates many cellular functions in development and disease. Although the molecular mechanisms of TGF-β signaling have been well studied, our understanding of this pathway is limited by the lack of tools that allow the control of TGF-β signaling with high spatiotemporal resolution. Here, we developed an optogenetic system (optoTGFBRs) that enables the precise control of TGF-β signaling in time and space. Using the optoTGFBRs system, we show that TGF-β signaling can be selectively and sequentially activated in single cells through the modulation of the pattern of light stimulations. By simultaneously monitoring the subcellular localization of TGF-β receptor and Smad2 proteins, we characterized the dynamics of TGF-β signaling in response to different patterns of blue light stimulations. The spatial and temporal precision of light control will make the optoTGFBRs system as a powerful tool for quantitative analyses of TGF-β signaling at the single cell level. © 2018 American Chemical Society-
dc.language영어-
dc.publisherAMER CHEMICAL SOC-
dc.titleSpatiotemporal Control of TGF-β Signaling with Light-
dc.typeArticle-
dc.type.rimsART-
dc.identifier.wosid000426012600017-
dc.identifier.scopusid2-s2.0-85042185959-
dc.identifier.rimsid62098ko
dc.contributor.affiliatedAuthorNury, Kim-
dc.contributor.affiliatedAuthorWon Do Heo-
dc.identifier.doi10.1021/acssynbio.7b00225-
dc.identifier.bibliographicCitationACS SYNTHETIC BIOLOGY, v.7, no.2, pp.443 - 451-
dc.relation.isPartOfACS SYNTHETIC BIOLOGY-
dc.citation.titleACS SYNTHETIC BIOLOGY-
dc.citation.volume7-
dc.citation.number2-
dc.citation.startPage443-
dc.citation.endPage451-
dc.description.journalClass1-
dc.description.journalClass1-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.subject.keywordAuthorcell signaling-
dc.subject.keywordAuthoroptogenetics-
dc.subject.keywordAuthorSmad2-
dc.subject.keywordAuthorTGF-beta-
Appears in Collections:
Center for Cognition and Sociality(인지 및 사회성 연구단) > 1. Journal Papers (저널논문)
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