BROWSE

Related Scientist

Researcher

Gandhamsetty Narasimhulu
분자활성 촉매반응 연구단
more info

Boron-Catalyzed Hydrogenative Reduction of Substituted Quinolines to Tetrahydroquinolines with Hydrosilanes

Cited 3 time in webofscience Cited 0 time in scopus
155 Viewed 10 Downloaded
Title
Boron-Catalyzed Hydrogenative Reduction of Substituted Quinolines to Tetrahydroquinolines with Hydrosilanes
Author(s)
Narasimhulu Gandhamsetty; Sehoon Park; Sukbok Chang
Publication Date
2017-11
Journal
SYNLETT, v.28, no.18, pp.2396 - 2400
Publisher
GEORG THIEME VERLAG KG
Abstract
A metal-free procedure for the hydrogenative reduction of substituted N-heteroaromatics has been developed by using hydrosilanes as reducing agents. The optimized conditions were successfully applied to the reactions of quinolines, quinoxalines, and quinoline N -oxides. They were also effective for the reduction of quinolines bearing amino or hydroxy groups, where H 2 was evolved through dehydrogenative silylation of the amine or hydroxy moieties. Preliminary mechanistic studies revealed that the initial step in the catalytic cycle involves 1,4-addition of the hydrosilane to the quinoline to give a 1,4-dihydroquinoline; this is followed by (transfer) hydrogenation to deliver the tetrahydroquinoline as the final product. © Georg Thieme Verlag Stuttgart.New York
URI
https://pr.ibs.re.kr/handle/8788114/4193
ISSN
0936-5214
Appears in Collections:
Center for Catalytic Hydrocarbon Functionalizations(분자활성 촉매반응 연구단) > Journal Papers (저널논문)
Files in This Item:
s-0036-1588442.pdfDownload

qrcode

  • facebook

    twitter

  • Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse