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식물노화·수명연구단
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MicroRNAs in brain aging

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dc.contributor.authorChand Parvez Danka Mohammed-
dc.contributor.authorJun Soo Park-
dc.contributor.authorHong Gil Nam-
dc.contributor.authorKeetae Kim-
dc.date.available2018-01-08T05:17:15Z-
dc.date.created2017-08-03-
dc.date.issued2017-12-
dc.identifier.issn0047-6374-
dc.identifier.urihttps://pr.ibs.re.kr/handle/8788114/4182-
dc.description.abstractBrain aging is one of the most crucial biological processes that affect the physiological balance betweenhealth and disease. Age-associated dysfunction of brain leads to severe health problems in current agingsociety. MicroRNAs (miRNAs) have emerged as important regulators in most physiological processesincluding fine-tuning of the short-term, cellular regulatory functions as well as modulation of long-termorganismal lifespan. In this review, we discuss critical roles of miRNAs in the progression of normal andpathological brain aging. 50% of all known miRNAs are found in brain including cortex and hippocam-pus. A significant number of expressed miRNAs were differentially regulated during aging, implicatingmiRNAs as regulators of brain aging. The ability of miRNAs to regulate multiple targets within a pathwayor even multiple pathways allows for coordinated regulation of brain functions. miRNA-mediated, brainfunctional changes are evident in cognition, inflammation, neuroprotection, lipid metabolism, mitochon-drial function and lifespan. Dysregulation of brain miRNAs contributes to accelerated cognitive declineand increased neurological disorders. Elucidating mechanisms by which miRNAs and their multiple tar-gets are temporally and spatially regulated in normal and pathological brain aging will provide a deeperunderstanding on the process of interrelated pathways of brain aging, and a new insight into therapeuticinterventions. © 2017 Elsevier B.V. All rights reserved.-
dc.description.uri1-
dc.language영어-
dc.publisherELSEVIER IRELAND LTD-
dc.subjectAging, microRNA, Brain, Target, Dysregulation-
dc.titleMicroRNAs in brain aging-
dc.typeArticle-
dc.type.rimsART-
dc.identifier.wosid000423006300002-
dc.identifier.scopusid2-s2.0-85010192488-
dc.identifier.rimsid59919ko
dc.date.tcdate2018-10-01-
dc.contributor.affiliatedAuthorChand Parvez Danka Mohammed-
dc.contributor.affiliatedAuthorHong Gil Nam-
dc.identifier.doi10.1016/j.mad.2017.01.007-
dc.identifier.bibliographicCitationMECHANISMS OF AGEING AND DEVELOPMENT, v.168, pp.3 - 9-
dc.citation.titleMECHANISMS OF AGEING AND DEVELOPMENT-
dc.citation.volume168-
dc.citation.startPage3-
dc.citation.endPage9-
dc.date.scptcdate2018-10-01-
dc.description.wostc4-
dc.description.scptc5-
dc.description.journalClass1-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.subject.keywordPlusTEMPORAL-LOBE EPILEPSY-
dc.subject.keywordPlusIMMATURE RAT MODEL-
dc.subject.keywordPlusNEURODEGENERATION-
dc.subject.keywordPlusINFLAMMATION-
dc.subject.keywordPlusHIPPOCAMPUS-
dc.subject.keywordPlusEXPRESSION-
dc.subject.keywordPlusNEURONS-
dc.subject.keywordPlusDISEASE-
dc.subject.keywordPlusMOUSE-
dc.subject.keywordPlusHOMEOSTASIS-
dc.subject.keywordAuthorAging-
dc.subject.keywordAuthormicroRNA-
dc.subject.keywordAuthorBrain-
dc.subject.keywordAuthorTarget-
dc.subject.keywordAuthorDysregulation-
Appears in Collections:
Center for Plant Aging Research (식물 노화·수명 연구단) > 1. Journal Papers (저널논문)
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