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Adaptive Encoding of Outcome Prediction by Prefrontal Cortex Ensembles Supports Behavioral Flexibility

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dc.contributor.authorDel Arco, A-
dc.contributor.authorPark, J-
dc.contributor.authorWood, J-
dc.contributor.authorYunbok Kim-
dc.contributor.authorMoghaddam, B-
dc.date.available2017-12-14T05:33:15Z-
dc.date.created2017-09-25-
dc.date.issued2017-08-
dc.identifier.issn0270-6474-
dc.identifier.urihttps://pr.ibs.re.kr/handle/8788114/4052-
dc.description.abstractThe prefrontal cortex (PFC) is thought to play a critical role in behavioral flexibility by monitoring action-outcome contingencies. How PFC ensembles represent shifts in behavior in response to changes in these contingencies remains unclear. We recorded single-unit activity and local field potentials in the dorsomedial PFC (dmPFC) of male rats during a set-shifting task that required them to update their behavior, among competing options, in response to changes in action-outcome contingencies. As behavior was updated, a subset of PFC ensembles encoded the current trial outcome before the outcome was presented. This novel outcome-prediction encoding was absent in a control task, in which actions were rewarded pseudorandomly, indicating that PFC neurons are not merely providing an expectancy signal. In both control and set-shifting tasks, dmPFC neurons displayed postoutcome discrimination activity, indicating that these neurons also monitor whether a behavior is successful in generating rewards. Gamma-power oscillatory activity increased before the outcome in both tasks but did not differentiate between expected outcomes, suggesting that this measure is not related to set-shifting behavior but reflects expectation of an outcome after action execution. These results demonstrate that PFC neurons support flexible rule-based action selection by predicting outcomes that follow a particular action. Copyright ©2017 the authors-
dc.description.uri1-
dc.language영어-
dc.publisherSOC NEUROSCIENCE-
dc.subjectcognitive flexibility-
dc.subjectdecision making-
dc.subjectgamma oscillations-
dc.subjectoutcome prediction-
dc.subjectsingle-unit recording-
dc.subjectworking memory-
dc.titleAdaptive Encoding of Outcome Prediction by Prefrontal Cortex Ensembles Supports Behavioral Flexibility-
dc.typeArticle-
dc.type.rimsART-
dc.identifier.wosid000408705100006-
dc.identifier.scopusid2-s2.0-85028660657-
dc.identifier.rimsid60185-
dc.date.tcdate2018-10-01-
dc.contributor.affiliatedAuthorYunbok Kim-
dc.identifier.doi10.1523/JNEUROSCI.0450-17.2017-
dc.identifier.bibliographicCitationJOURNAL OF NEUROSCIENCE, v.37, no.35, pp.8363 - 8373-
dc.citation.titleJOURNAL OF NEUROSCIENCE-
dc.citation.volume37-
dc.citation.number35-
dc.citation.startPage8363-
dc.citation.endPage8373-
dc.date.scptcdate2018-10-01-
dc.description.wostc1-
dc.description.scptc1-
dc.description.journalClass1-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.subject.keywordPlusANTERIOR CINGULATE CORTEX-
dc.subject.keywordPlusORBITOFRONTAL CORTEX-
dc.subject.keywordPlusGLUTAMATE RECEPTORS-
dc.subject.keywordPlusINTEGRATIVE THEORY-
dc.subject.keywordPlusDECISION-MAKING-
dc.subject.keywordPlusRAT-
dc.subject.keywordPlusREWARD-
dc.subject.keywordPlusNEURONS-
dc.subject.keywordPlusSIGNALS-
dc.subject.keywordPlusSTRIATUM-
dc.subject.keywordAuthorcognitive flexibility-
dc.subject.keywordAuthordecision making-
dc.subject.keywordAuthorgamma oscillations-
dc.subject.keywordAuthoroutcome prediction-
dc.subject.keywordAuthorsingle-unit recording-
dc.subject.keywordAuthorworking memory-
Appears in Collections:
Center for Neuroscience Imaging Research (뇌과학 이미징 연구단) > 1. Journal Papers (저널논문)
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