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Sandip Mulay
분자활성 촉매반응 연구단
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Nerve agent simulant diethyl chlorophosphate detection using a cyclization reaction approach with high stokes shift system

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Title
Nerve agent simulant diethyl chlorophosphate detection using a cyclization reaction approach with high stokes shift system
Author(s)
Yoon Jeong Jang; Sandip V. Mulay; Youngsam Kim; Perman Jorayev; David G. Churchill
Publication Date
2017-02
Journal
NEW JOURNAL OF CHEMISTRY, v.41, no.4, pp.1653 - 1658
Publisher
ROYAL SOC CHEMISTRY
Abstract
A reaction-based fluorescent probe (CoumNMe2) containing a coumarin-4-dimethyaminoaryl scaffold for the detection of nerve agent simulants was developed. The probe showed fluorescence enhancement selectively with diethyl chlorophosphate (DCP) over close competitors diethyl cyanophosphonate (DECP), and diethyl methylphosphonate (DEMP) with very little interference from metal ions. O-P bond formation by reaction of the benzyl alcohol motif on the probe with DCP, favours intramolecular cyclization that leads to the ammonium salt. The cyclization strongly inhibits the photo-induced electron transfer (PET) process, which leads to the enhancement of fluorescence intensity (∼10 fold). Also, DFT/TDDFT calculations were exploited to explain the nature of the fluorescence “turn-on” process. Herein, we report a new fluorescent probe (CoumNMe2) based on the intramolecular cyclization reaction for the detection of nerve agent simulant and has potential for real applications. © The Royal Society of Chemistry and the Centre National de la Recherche Scientifique
URI
https://pr.ibs.re.kr/handle/8788114/3766
ISSN
1144-0546
Appears in Collections:
Center for Catalytic Hydrocarbon Functionalizations(분자활성 촉매반응 연구단) > Journal Papers (저널논문)
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