Separation or binding? Role of the dentate gyrus in hippocampal mnemonic processing

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Title
Separation or binding? Role of the dentate gyrus in hippocampal mnemonic processing
Author(s)
Jong Won Lee; Min Whan Jung
Publication Date
2017-04
Journal
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, v.75, no., pp.183 - 194
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Abstract
As a major component of the hippocampal trisynaptic circuit, the dentate gyrus (DG) relays inputs from the entorhinal cortex to the CA3 subregion. Although the anatomy of the DG is well characterized, its contribution to hippocampal mnemonic processing is still unclear. A currently popular theory proposes that the primary function of the DG is to orthogonalize incoming input patterns into non-overlapping patterns (pattern separation). We critically review the available data and conclude that the theoretical support and empirical evidence for this theory are not strong. We then review an alternative theory that posits a role for the DG in binding together different types of incoming sensory information. We conclude that ‘binding’ better captures the contribution of the DG to memory encoding than ‘pattern separation’. © 2017 Elsevier Lt
URI
https://pr.ibs.re.kr/handle/8788114/3396
ISSN
0149-7634
Appears in Collections:
Center for Synaptic Brain Dysfunctions(시냅스 뇌질환 연구단) > Journal Papers (저널논문)
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