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Gastric Carcinogenesis in the miR-222/221 Transgenic Mouse Model

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dc.contributor.authorChoi, B-
dc.contributor.authorYu, J-
dc.contributor.authorHan, TS-
dc.contributor.authorYoung-Kook Kim-
dc.contributor.authorHur, K-
dc.contributor.authorKang, BC-
dc.contributor.authorKim, WH-
dc.contributor.authorKim, DY-
dc.contributor.authorLee, HJ-
dc.contributor.authorV. Narry Kim-
dc.contributor.authorYang, HK-
dc.date.available2017-03-22T01:53:57Z-
dc.date.created2017-02-24ko
dc.date.issued2017-01-
dc.identifier.issn1598-2998-
dc.identifier.urihttps://pr.ibs.re.kr/handle/8788114/3382-
dc.description.abstractPurpose MicroRNAs (miRNAs) regulate various cellular functions, including development, cell proliferation, apoptosis, and tumorigenesis. Different signatures associated with various tissue types, diagnosis, progression, prognosis, staging, and treatment response have been identified by miRNA expression profiling of human tumors. miRNAs function as oncogenes or as tumor suppressors. The relationship between gastric cancer and miRNA garnered attention due to the high incidence of gastric cancer in Asian countries. miR-222/221 expression increases in gastric tumor tissues. The oncogenic effect of miR-222/221 was previously determined in functional studies and xenograft models. In this study, transgenic mice over expressing miR-222/221 were generated to confirm the effect of miR-222/221 on gastric carcinogenesis. Materials and Methods At 6 weeks of age, 65 transgenic mice and 53 wild-type mice were given drinking water containing N-nitroso-N-methylurea (MNU) for 5 alternating weeks to induce gastric cancer. The mice were euthanized at 36 weeks of age and histologic analysis was performed. Results Hyperplasia was observed in 3.77% of the wild-type mice and in 18.46% of the transgenic mice (p=0.020). Adenoma was observed in 20.75% of the wild-type mice and 26.15% of the transgenic mice (p=0.522). Carcinoma was observed in 32.08% of the wild type mice and 41.54% of the transgenic mice (p=0.341). The frequency of hyperplasia, adenoma, and carcinoma was higher in transgenic mice, but the difference was statistically significant only in hyperplasia. Conclusion These results suggest that hyperplasia, a gastric pre-cancerous lesion, is associated with miR-222/221 expression but miR-222/221 expression does not affect tumorigenesis itself. ⓒ2017 by the Korean Cancer Association-
dc.description.uri1-
dc.language영어-
dc.publisherKOREAN CANCER ASSOCIATION-
dc.subjectmicroRNAs-
dc.subjectTransgenic mouse-
dc.subjectStomach neoplasms-
dc.subjectGastric carcinogenesis-
dc.subjectMNU (N-nitroso-N-methylurea)-
dc.titleGastric Carcinogenesis in the miR-222/221 Transgenic Mouse Model-
dc.typeArticle-
dc.type.rimsART-
dc.identifier.wosid000391899800016-
dc.identifier.scopusid2-s2.0-85010341430-
dc.identifier.rimsid58816ko
dc.date.tcdate2018-10-01-
dc.contributor.affiliatedAuthorYoung-Kook Kim-
dc.contributor.affiliatedAuthorV. Narry Kim-
dc.identifier.doi10.4143/crt.2015.462-
dc.identifier.bibliographicCitationCANCER RESEARCH AND TREATMENT, v.49, no.1, pp.150 - 160-
dc.citation.titleCANCER RESEARCH AND TREATMENT-
dc.citation.volume49-
dc.citation.number1-
dc.citation.startPage150-
dc.citation.endPage160-
dc.date.scptcdate2018-10-01-
dc.description.wostc1-
dc.description.scptc1-
dc.description.journalClass1-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.description.journalRegisteredClasskci-
dc.subject.keywordPlusMETHYL-N-NITROSOUREA-
dc.subject.keywordPlusCELL-CYCLE-
dc.subject.keywordPlusCANCER-
dc.subject.keywordPlusMICRORNAS-
dc.subject.keywordPlusMICE-
dc.subject.keywordPlusEXPRESSION-
dc.subject.keywordPlusPROLIFERATION-
dc.subject.keywordPlusCARCINOMAS-
dc.subject.keywordPlusRNAS-
dc.subject.keywordAuthormicroRNAs-
dc.subject.keywordAuthorTransgenic mouse-
dc.subject.keywordAuthorStomach neoplasms-
dc.subject.keywordAuthorGastric carcinogenesis-
dc.subject.keywordAuthorMNU (N-nitroso-N-methylurea)-
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Center for RNA Research(RNA 연구단) > 1. Journal Papers (저널논문)
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