Diacylglycerol kinases in the coordination of synaptic plasticity

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Title
Diacylglycerol kinases in the coordination of synaptic plasticity
Author(s)
Dongwon Lee; Eunjoon Kim; Keiko Tanaka-Yamamoto
Publication Date
2016-08
Journal
Frontiers in cell and developmental biology, v.4, no., pp.92 -
Publisher
Lausanne : Frontiers Media S.A.
Abstract
Synaptic plasticity is activity-dependent modification of the efficacy of synaptic transmission. Although, detailed mechanisms underlying synaptic plasticity are diverse and vary at different types of synapses, diacylglycerol (DAG)-associated signaling has been considered as an important regulator of many forms of synaptic plasticity, including long-term potentiation (LTP) and long-term depression (LTD). Recent evidences indicate that DAG kinases (DGKs), which phosphorylate DAG to phosphatidic acid to terminate DAG signaling, are important regulators of LTP and LTD, as supported by the results from mice lacking specific DGK isoforms. This review will summarize these studies and discuss how specific DGK isoforms distinctly regulate different forms of synaptic plasticity at pre- and postsynaptic sites. In addition, we propose a general role of DGKs as coordinators of synaptic plasticity that make local synaptic environments more permissive for synaptic plasticity by regulating DAG concentration and interacting with other synaptic proteins.
URI
https://pr.ibs.re.kr/handle/8788114/3282
ISSN
2296-634X
Appears in Collections:
Center for Synaptic Brain Dysfunctions(시냅스 뇌질환 연구단) > Journal Papers (저널논문)
Files in This Item:
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