Synaptic actin dysregulation, a convergent mechanism of mental disorders?

Cited 16 time in webofscience Cited 0 time in scopus
193 Viewed 4 Downloaded
Title
Synaptic actin dysregulation, a convergent mechanism of mental disorders?
Author(s)
Zhen Yan; Eunjoon Kim; Dibyadeep Datta; David A. Lewis; Scott H. Soderling
Publication Date
2016-11
Journal
JOURNAL OF NEUROSCIENCE, v.36, no.45, pp.11411 - 11417
Publisher
SOC NEUROSCIENCE
Abstract
Actin polymerization governs activity-dependent modulation of excitatory synapses, including their morphology and functionality. It is clear from human genetics that neuropsychiatric and neurodevelopmental disturbances are multigenetic in nature, highlighting the need to better understand the critical neural pathways associated with these disorders and how they are altered by genetic risk alleles. One such signaling pathway that is heavily implicated by candidate genes for psychiatric and neurodevelopmental disorders are regulators of signaling to the actin cytoskeleton, suggesting that its disruption and the ensuring abnormalities of spine structures and postsynaptic complexes is a commonly affected pathway in brain disorders. This review will discuss recent experimental findings that strongly support genetic evidence linking the synaptic cytoskeleton to mental disorders, such as schizophrenia and autism spectrum disorders. ©2016 the authors
URI
https://pr.ibs.re.kr/handle/8788114/3234
ISSN
0270-6474
Appears in Collections:
Center for Synaptic Brain Dysfunctions(시냅스 뇌질환 연구단) > Journal Papers (저널논문)
Files in This Item:
2016_134.pdfDownload

qrcode

  • facebook

    twitter

  • Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse