BROWSE

Related Scientist

Researcher

정효빈
식물 노화·수명 연구단
more info

Functional characterization of EI24-induced autophagy in the degradation of RING-domain E3 ligases

DC Field Value Language
dc.contributor.authorDevkota, S-
dc.contributor.authorHyobin Jeong-
dc.contributor.authorKim, Y-
dc.contributor.authorAli, M-
dc.contributor.authorRoh, JI-
dc.contributor.authorDaehee Hwang-
dc.contributor.authorLee, HW-
dc.date.available2017-01-05T01:51:00Z-
dc.date.created2016-12-19-
dc.date.issued2016-11-
dc.identifier.issn1554-8627-
dc.identifier.urihttps://pr.ibs.re.kr/handle/8788114/3158-
dc.description.abstractHistorically, the ubiquitin-proteasome system (UPS) and autophagy pathways were believed to be independent; however, recent data indicate that these pathways engage in crosstalk. To date, the players mediating this crosstalk have been elusive. Here, we show experimentally that EI24 (EI24, autophagy associated transmembrane protein), a key component of basal macroautophagy/autophagy, degrades 14 physiologically important E3 ligases with a RING (really interesting new gene) domain, whereas 5 other ligases were not degraded. Based on the degradation results, we built a statistical model that predicts the RING E3 ligases targeted by EI24 using partial least squares discriminant analysis. Of 381 RING E3 ligases examined computationally, our model predicted 161 EI24 targets. Those targets are primarily involved in transcription, proteolysis, cellular bioenergetics, and apoptosis and regulated by TP53 and MTOR signaling. Collectively, our work demonstrates that EI24 is an essential player in UPS-autophagy crosstalk via degradation of RING E3 ligases. These results indicate a paradigm shift regarding the fate of E3 ligases. © 2016 Sushil Devkota, Hyobin Jeong, Yunmi Kim, Muhammad Ali, Jae-il Roh, Daehee Hwang, and Han-Woong Lee. Published with license by Taylor & Francis.-
dc.languageENG-
dc.publisherLANDES BIOSCIENCE-
dc.titleFunctional characterization of EI24-induced autophagy in the degradation of RING-domain E3 ligases-
dc.typeArticle-
dc.type.rimsA-
dc.identifier.wosid000387665000007-
dc.identifier.scopusid2-s2.0-84987924695-
dc.description.wostc6-
dc.date.tcdate2018-10-01-
dc.date.scptcdate2018-10-01-
dc.subject.keywordautophagy-
dc.subject.keywordcomputational biology-
dc.subject.keywordE3 ligase-
dc.subject.keywordEI24-
dc.subject.keywordproteasome-
dc.subject.keywordRING-domain-
dc.contributor.affiliatedAuthorHyobin Jeong-
dc.contributor.affiliatedAuthorDaehee Hwang-
dc.identifier.bibliographicCitationAUTOPHAGY, v.12, no.11, pp.2038 - 2053-
dc.description.scptc6-
Appears in Collections:
Center for Plant Aging Research (식물 노화·수명 연구단) > Journal Papers (저널논문)
Files in This Item:
15.Functional characterization of EI24 induced autophagy in the degradation of RING domain E3 ligases.pdfDownload

qrcode

  • facebook

    twitter

  • Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse