Distinct Roles of Parvalbumin- and Somatostatin-Expressing Interneurons in Working Memory

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Title
Distinct Roles of Parvalbumin- and Somatostatin-Expressing Interneurons in Working Memory
Author(s)
Dohoung Kim; Huijeong Jeong; Juhyeong Lee; Jeong-Wook Ghim; Eun Sil Her; Seung-Hee Lee; Min Whan Jung
Publication Date
2016-11
Journal
NEURON, v.92, no.4, pp.902 - 915
Publisher
CELL PRESS
Abstract
Inhibitory interneurons are thought to play crucial roles in diverse brain functions. However, roles of different inhibitory interneuron subtypes in working memory remain unclear. We found distinct activity patterns and stimulation effects of two major interneuron subtypes, parvalbumin (PV)- and somatostatin (SOM)-expressing interneurons, in the medial prefrontal cortex of mice performing a spatial working memory task. PV interneurons showed weak target-dependent delay-period activity and were strongly inhibited by reward. By contrast, SOM interneurons showed strong target-dependent delay-period activity, and only a subtype of them was inhibited by reward. Furthermore, optogenetic stimulation of PV and SOM interneurons preferentially suppressed discharges of putative pyramidal cells and interneurons, respectively. These results indicate different contributions of PV and SOM interneurons to prefrontal cortical circuit dynamics underlying working memory. © 2016 Elsevier Inc.
URI
https://pr.ibs.re.kr/handle/8788114/3090
ISSN
0896-6273
Appears in Collections:
Center for Synaptic Brain Dysfunctions(시냅스 뇌질환 연구단) > Journal Papers (저널논문)
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