SALM5 trans-synaptically interacts with LAR-RPTPs in a splicing-dependent manner to regulate synapse development

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Title
SALM5 trans-synaptically interacts with LAR-RPTPs in a splicing-dependent manner to regulate synapse development
Author(s)
Yeonsoo Choi; Jungyong Nam; Daniel J. Whitcomb; Yoo Sung Song; Doyoun Kim; Sangmin Jeon; Ji Won Um; Seong-Gyu Lee; Jooyeon Woo; Seok-Kyu Kwon; Yan Li; Won Mah; Ho Min Kim; Jaewon Ko; Kwangwook Cho; Eunjoon Kim
Publication Date
2016-05
Journal
SCIENTIFIC REPORTS, v.6, no., pp.26676 -
Publisher
NATURE PUBLISHING GROUP
Abstract
Synaptogenic adhesion molecules play critical roles in synapse formation. SALM5/Lrfn5, a SALM/Lrfn family adhesion molecule implicated in autism spectrum disorders (ASDs) and schizophrenia, induces presynaptic differentiation in contacting axons, but its presynaptic ligand remains unknown. We found that SALM5 interacts with the Ig domains of LAR family receptor protein tyrosine phosphatases (LAR-RPTPs; LAR, PTPδ, and PTPσ). These interactions are strongly inhibited by the splice insert B in the Ig domain region of LAR-RPTPs, and mediate SALM5-dependent presynaptic differentiation in contacting axons. In addition, SALM5 regulates AMPA receptor-mediated synaptic transmission through mechanisms involving the interaction of postsynaptic SALM5 with presynaptic LAR-RPTPs. These results suggest that postsynaptic SALM5 promotes synapse development by trans-synaptically interacting with presynaptic LAR-RPTPs and is important for the regulation of excitatory synaptic strength.
URI
https://pr.ibs.re.kr/handle/8788114/2671
ISSN
2045-2322
Appears in Collections:
Center for Synaptic Brain Dysfunctions(시냅스 뇌질환 연구단) > Journal Papers (저널논문)
Files in This Item:
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