Synaptic adhesion molecule IgSF11 regulates synaptic transmission and plasticity

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Title
Synaptic adhesion molecule IgSF11 regulates synaptic transmission and plasticity
Author(s)
Seil Jang; Daeyoung Oh; Yeunkum Lee; Eric Hosy; Hyewon Shin; Christoph van Riesen; Daniel Whitcomb; Julia M Warburton; Jihoon Jo; Doyoun Kim; Sun Gyun Kim; Seung Min Um; Seok-kyu Kwon; Myoung-Hwan Kim; Junyeop Daniel Roh; Jooyeon Woo; Heejung Jun; Dongmin Lee; Won Mah; Hyun Kim; Bong-Kiun Kaang; Kwangwook Cho; Jeong-Seop Rhee; Daniel Choquet; Eunjoon Kim
Publication Date
2016-01
Journal
NATURE NEUROSCIENCE, v.19, no.1, pp.84 -
Publisher
NATURE PUBLISHING GROUP
Abstract
Synaptic adhesion molecules regulate synapse development and plasticity through mechanisms that include trans-synaptic adhesion and recruitment of diverse synaptic proteins. We found that the immunoglobulin superfamily member 11 (IgSF11), a homophilic adhesion molecule that preferentially expressed in the brain, is a dual-binding partner of the postsynaptic scaffolding protein PSD-95 and AMPA glutamate receptors (AMPARs). IgSF11 required PSD-95 binding for its excitatory synaptic localization. In addition, IgSF11 stabilized synaptic AMPARs, as determined by IgSF11 knockdown-induced suppression of AMPAR-mediated synaptic transmission and increased surface mobility of AMPARs, measured by high-throughput, single-molecule tracking. IgSF11 deletion in mice led to the suppression of AMPAR-mediated synaptic transmission in the dentate gyrus and long-term potentiation in the CA1 region of the hippocampus. IgSF11 did not regulate the functional characteristics of AMPARs, including desensitization, deactivation or recovery. These results suggest that IgSF11 regulates excitatory synaptic transmission and plasticity through its tripartite interactions with PSD-95 and AMPARs. © 2015 Nature America, Inc. All rights reserved.
URI
https://pr.ibs.re.kr/handle/8788114/2664
ISSN
1097-6256
Appears in Collections:
Center for Synaptic Brain Dysfunctions(시냅스 뇌질환 연구단) > Journal Papers (저널논문)
Files in This Item:
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