IQ Motif and SEC7 Domain-containing Protein 3 (IQSEC3) Interacts with Gephyrin to Promote Inhibitory Synapse Formation

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Title
IQ Motif and SEC7 Domain-containing Protein 3 (IQSEC3) Interacts with Gephyrin to Promote Inhibitory Synapse Formation
Author(s)
Ji Won Um; Gayoung Choii; Dongseok Park; Dongwook Kim; Sangmin Jeon; Hyeyeon Kang; Takuma Mori; Theofilos Papadopoulos; Taesun Yoo; Yeunkum Lee; Eunjoon Kim; TKatsuhiko abuchi; Jaewon Ko
Publication Date
2016-05
Journal
JOURNAL OF BIOLOGICAL CHEMISTRY, v.291, no.19, pp.10119 - 10130
Publisher
AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
Abstract
Gephyrin is a central scaffold protein that mediates development, function, and plasticity of mammalian inhibitory synapses by interacting with various inhibitory synaptic proteins. Here, we show that IQSLC3, a guanine nucleotide exchange factor for ARE6, directly interacts with gephyrin, an interaction that is critical for the inhibitory synapse localization of IQSEC3. Overexpression of IQSEC3 increases inhibitory, but not excitatory, synapse density in a guanine nucleotide exchange factor activity-dependent manner. Conversely, knockdown of IQSEC3 decreases size of gephyrin cluster without altering gephyrin puncta density. Collectively, these data reveal that IQSEC3 acts together with gephyrin to regulate inhibitory synapse development. © 2016 by The American Society for Biochemistry and Molecular Biology, Inc.
URI
https://pr.ibs.re.kr/handle/8788114/2661
ISSN
0021-9258
Appears in Collections:
Center for Synaptic Brain Dysfunctions(시냅스 뇌질환 연구단) > Journal Papers (저널논문)
Files in This Item:
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