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뇌과학이미징연구단
뇌과학 이미징 연구단
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Using Tractography to Distinguish SWEDD from Parkinson's Disease Patients Based on Connectivity

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dc.contributor.authorKim, M-
dc.contributor.authorHyunjin Park-
dc.date.available2016-05-12T08:53:19Z-
dc.date.created2016-04-18-
dc.date.issued2016-02-
dc.identifier.issn2090-8083-
dc.identifier.urihttp://pr.ibs.re.kr/handle/8788114/2494-
dc.description.abstractBackground. It is critical to distinguish between Parkinson's disease (PD) and scans without evidence of dopaminergic deficit (SWEDD), because the two groups are different and require different therapeutic approaches. Objective. The aim of this study was to distinguish SWEDD patients from PD patients using connectivity information derived from diffusion tensor imaging tractography. Methods. Diffusion magnetic resonance images of SWEDD (n = 37) and PD (n = 40) were obtained from a research database. Tractography, the process of obtaining neural fiber information, was performed using custom software. Group-wise differences between PD and SWEDD patients were quantified using the number of connected fibers between two regions, and correlation analyses were performed based on clinical scores. A support vector machine classifier (SVM) was applied to distinguish PD and SWEDD based on group-wise differences. Results. Four connections showed significant group-wise differences and correlated with the Unified Parkinson's Disease Rating Scale sponsored by the Movement Disorder Society. The SVM classifier attained 77.92% accuracy in distinguishing between SWEDD and PD using these identified connections. Conclusions. The connections and regions identified represent candidates for future research investigations. © 2016 M. Kim and H. Park.This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.-
dc.languageENG-
dc.titleUsing Tractography to Distinguish SWEDD from Parkinson's Disease Patients Based on Connectivity-
dc.typeArticle-
dc.type.rimsA-
dc.identifier.wosid000372279500001-
dc.identifier.scopusid2-s2.0-84962010374-
dc.description.wostc2-
dc.date.tcdate2018-10-01-
dc.date.scptcdate2018-10-01-
dc.contributor.affiliatedAuthorHyunjin Park-
dc.identifier.bibliographicCitationParkinsons Disease, v.2016, no., pp.8704910 --
dc.description.scptc6-
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Center for Neuroscience Imaging Research (뇌과학 이미징 연구단) > Journal Papers (저널논문)
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