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Adaptation of cortical activity to sustained pressure stimulation on the fingertip

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dc.contributor.authorYoon Gi Chungko
dc.contributor.authorSang Woo Hanko
dc.contributor.authorHyung‑Sik Kimko
dc.contributor.authorSoon‑Cheol Chungko
dc.contributor.authorJang-Yeon Parkko
dc.contributor.authorChristian Wallravenko
dc.contributor.authorSung‑Phil Kimko
dc.date.available2016-01-25T00:12:42Z-
dc.date.created2015-11-16ko
dc.date.issued201510ko
dc.identifier.issn1471-2202ko
dc.identifier.urihttp://pr.ibs.re.kr/handle/8788114/2306ko
dc.description.abstractBackground: Tactile adaptation is a phenomenon of the sensory system that results in temporal desensitization after an exposure to sustained or repetitive tactile stimuli. Previous studies reported psychophysical and physiological adaptation where perceived intensity and mechanoreceptive afferent signals exponentially decreased during tactile adaptation. Along with these studies, we hypothesized that somatosensory cortical activity in the human brain also exponentially decreased during tactile adaptation. The present neuroimaging study specifically investigated temporal changes in the human cortical responses to sustained pressure stimuli mediated by slow-adapting type I afferents. Methods: We applied pressure stimulation for up to 15 s to the right index fingertip in 21 healthy participants and acquired functional magnetic resonance imaging (fMRI) data using a 3T MRI system. We analyzed cortical responses in terms of the degrees of cortical activation and inter-regional connectivity during sustained pressure stimulation. Results: Our results revealed that the degrees of activation in the contralateral primary and secondary somatosensory cortices exponentially decreased over time and that intra-and inter-hemispheric inter-regional functional connectivity over the regions associated with tactile perception also linearly decreased or increased over time, during pressure stimulation. Conclusion: These results indicate that cortical activity dynamically adapts to sustained pressure stimulation mediated by SA-I afferents, involving changes in the degrees of activation on the cortical regions for tactile perception as well as in inter-regional functional connectivity among them. We speculate that these adaptive cortical activity may represent an efficient cortical processing of tactile information. © 2015 Chung et al. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License(http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.ko
dc.languageENGko
dc.publisherBIOMED CENTRAL LTDko
dc.titleAdaptation of cortical activity to sustained pressure stimulation on the fingertipko
dc.typeARTICLEko
dc.type.rimsAko
dc.identifier.wosid000363624300001ko
dc.identifier.scopusid2-s2.0-84947036575ko
dc.identifier.pid362null
dc.description.wostc2-
dc.date.scptcdate2018-10-01-
dc.subject.keywordSomatosensory cortex-
dc.subject.keywordTactile adaptation-
dc.subject.keywordPressure-
dc.subject.keywordFunctional connectivity-
dc.subject.keywordfMRI-
dc.identifier.doi10.1186/s12868-015-0207-xko
dc.identifier.bibliographicCitationBMC NEUROSCIENCE, v.16, no.71, pp.1 - 11ko
dc.date.tcdate2018-10-01-
dc.description.scptc3-
dc.type.docTypeArticle-
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Center for Neuroscience Imaging Research (뇌과학 이미징 연구단) > Journal Papers (저널논문)
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