Acute loss of TET function results in aggressive myeloid cancer in mice
DC Field | Value | Language |
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dc.contributor.author | Jungeun An | - |
dc.contributor.author | González-Avalos, E. | - |
dc.contributor.author | Chawla, A. | - |
dc.contributor.author | Jeong, M. | - |
dc.contributor.author | López-Moyado, I.F. | - |
dc.contributor.author | Li, W. | - |
dc.contributor.author | Goodell, M.A. | - |
dc.contributor.author | Chavez, L. | - |
dc.contributor.author | Ko, M. | - |
dc.contributor.author | Rao, A. | - |
dc.date.available | 2016-01-25T00:11:42Z | - |
dc.date.created | 2015-12-07 | ko |
dc.date.issued | 2015-11 | - |
dc.identifier.issn | 2041-1723 | - |
dc.identifier.uri | https://pr.ibs.re.kr/handle/8788114/2248 | - |
dc.description.abstract | TET-family dioxygenases oxidize 5-methylcytosine (5mC) in DNA, and exert tumour suppressor activity in many types of cancers. Even in the absence of TET coding region mutations, TET loss-of-function is strongly associated with cancer. Here we show that acute elimination of TET function induces the rapid development of an aggressive, fully-penetrant and cell-autonomous myeloid leukaemia in mice, pointing to a causative role for TET loss-of-function in this myeloid malignancy. Phenotypic and transcriptional profiling shows aberrant differentiation of haematopoietic stem/progenitor cells, impaired erythroid and lymphoid differentiation and strong skewing to the myeloid lineage, with only a mild relation to changes in DNA modification. We also observe progressive accumulation of phospho-H2AX and strong impairment of DNA damage repair pathways, suggesting a key role for TET proteins in maintaining genome integrity. | - |
dc.description.uri | 1 | - |
dc.language | 영어 | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.title | Acute loss of TET function results in aggressive myeloid cancer in mice | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.identifier.wosid | 000366377600001 | - |
dc.identifier.scopusid | 2-s2.0-84948446391 | - |
dc.identifier.rimsid | 21735 | ko |
dc.date.tcdate | 2018-10-01 | - |
dc.contributor.affiliatedAuthor | Jungeun An | - |
dc.identifier.doi | 10.1038/ncomms10071 | - |
dc.identifier.bibliographicCitation | NATURE COMMUNICATIONS, v.6, pp.10071 | - |
dc.citation.title | NATURE COMMUNICATIONS | - |
dc.citation.volume | 6 | - |
dc.citation.startPage | 10071 | - |
dc.date.scptcdate | 2018-10-01 | - |
dc.description.wostc | 37 | - |
dc.description.scptc | 40 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |