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Glassy carbon electrodes deliver unpredictable reduction potentials for platinum(IV) antitumor prodrugs

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Title
Glassy carbon electrodes deliver unpredictable reduction potentials for platinum(IV) antitumor prodrugs
Author(s)
McCormick M.C.; Schultz F.A.; Mu-Hyun Baik
Publication Date
2016-01
Journal
POLYHEDRON, v.103, no., pp.28 - 34
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Abstract
Reductive activation of six-coordinate Pt(IV) complexes to afford square-planar Pt(II) complexes has exhibited surprisingly divergent and unpredictable cathodic peak potentials during cyclic voltammetry (CV) measurements under widely employed experimental conditions. A systematic, detailed investigation reveals that glassy carbon (GC) electrodes are responsible for this erratic behavior. More reproducible CVs are obtained with platinum metal electrodes, which display cathodic responses at much more positive potentials. The unreliable and negatively shifted peak potentials observed at GC are attributed to a non-uniform oxide layer that is formed on the electrode surface causing slow electron transfer. A simple procedure of repetitive scanning to reducing potentials is found to be effective for cleaning and activating the GC surface, such that it exhibits the more consistent and accurate peak potential responses seen with a Pt electrode. © 2015 Elsevier Ltd.All rights reserved
URI
https://pr.ibs.re.kr/handle/8788114/2205
ISSN
0277-5387
Appears in Collections:
Center for Catalytic Hydrocarbon Functionalizations(분자활성 촉매반응 연구단) > Journal Papers (저널논문)
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