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Parasitic Nematode-Induced CD4+Foxp3+T Cells Can Ameliorate Allergic Airway Inflammation

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dc.contributor.authorKang S.A.-
dc.contributor.authorPark M.-K.-
dc.contributor.authorCho M.K.-
dc.contributor.authorPark S.K.-
dc.contributor.authorMin Seong Jang-
dc.contributor.authorBo-Gie Yang-
dc.contributor.authorMyoung Ho Jang-
dc.contributor.authorKim D.-H.-
dc.contributor.authorYu H.S.-
dc.date.available2016-01-07T09:16:25Z-
dc.date.created2015-05-18ko
dc.date.issued2014-12-
dc.identifier.issn1935-2735-
dc.identifier.urihttps://pr.ibs.re.kr/handle/8788114/2180-
dc.description.abstractBackground: The recruitment of CD4+CD25+Foxp3+T (Treg) cells is one of the most important mechanisms by which parasites down-regulate the immune system. Methodology/Principal Findings: We compared the effects of Treg cells from Trichinella spiralis-infected mice and uninfected mice on experimental allergic airway inflammation in order to understand the functions of parasite-induced Treg cells. After four weeks of T. spiralis infection, we isolated Foxp3-GFP-expressing cells from transgenic mice using a cell sorter. We injected CD4+Foxp3+ cells from T. spiralis-infected [Inf(+)Foxp3+] or uninfected [Inf(-)Foxp3+] mice into the tail veins of C57BL/6 mice before the induction of inflammation or during inflammation. Inflammation was induced by ovalbumin (OVA)-alum sensitization and OVA challenge. The concentrations of the Th2-related cytokines IL-4, IL-5, and IL-13 in the bronchial alveolar lavage fluid and the levels of OVA-specific IgE and IgG1 in the serum were lower in mice that received intravenous application of Inf(+)Foxp3+ cells [IV(inf):+(+) group] than in control mice. Some features of allergic airway inflammation were ameliorated by the intravenous application of Inf(-)Foxp3+ cells [IV(inf):+(-) group], but the effects were less distinct than those observed in the IV(inf):+(+) group. We found that Inf(+)Foxp3+ cells migrated to inflammation sites in the lung and expressed higher levels of Treg-cell homing receptors (CCR5 and CCR9) and activation markers (Klrg1, Capg, GARP, Gzmb, OX40) than did Inf(-)Foxp3+ cells. Conclusion/Significance: T. spiralis infection promotes the proliferation and functional activation of Treg cells. Parasiteinduced Treg cells migrate to the inflammation site and suppress immune responses more effectively than non-parasiteinduced Treg cells. The adoptive transfer of Inf(+)Foxp3+ cells is an effective method for the treatment and prevention of allergic airway diseases in mice and is a promising therapeutic approach for the treatment of allergic airway diseases. (c) 2014 Kang et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.-
dc.description.uri1-
dc.language영어-
dc.publisherPUBLIC LIBRARY SCIENCE-
dc.titleParasitic Nematode-Induced CD4+Foxp3+T Cells Can Ameliorate Allergic Airway Inflammation-
dc.typeArticle-
dc.type.rimsART-
dc.identifier.wosid000346701000061-
dc.identifier.scopusid2-s2.0-84928243264-
dc.identifier.rimsid19645ko
dc.date.tcdate2018-10-01-
dc.contributor.affiliatedAuthorMin Seong Jang-
dc.contributor.affiliatedAuthorBo-Gie Yang-
dc.contributor.affiliatedAuthorMyoung Ho Jang-
dc.identifier.doi10.1371/journal.pntd.0003410-
dc.identifier.bibliographicCitationPLOS NEGLECTED TROPICAL DISEASES, v.8, no.12, pp.e3410-
dc.citation.titlePLOS NEGLECTED TROPICAL DISEASES-
dc.citation.volume8-
dc.citation.number12-
dc.citation.startPagee3410-
dc.date.scptcdate2018-10-01-
dc.description.wostc8-
dc.description.scptc9-
dc.description.journalClass1-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
Appears in Collections:
Academy of Immunology and Microbiology(면역 미생물 공생 연구단) > 1. Journal Papers (저널논문)
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28. (2014.12-Plos) Parasitic Nematode-induced CD4+Foxp3+T cells can ameliorate.pdfDownload

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