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분자활성촉매반응연구단
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Exceptional time response, stability and selectivity in doubly-activated phenyl selenium-based glutathione-selective platform

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dc.contributor.authorYoungsam Kim-
dc.contributor.authorSandip V. Mulay-
dc.contributor.authorChoi, M.-
dc.contributor.authorYu, S.B.-
dc.contributor.authorJon, S.-
dc.contributor.authorDavid G. Churchill-
dc.date.available2016-01-07T09:16:07Z-
dc.date.created2015-10-06-
dc.date.issued2015-07-
dc.identifier.issn2041-6520-
dc.identifier.urihttps://pr.ibs.re.kr/handle/8788114/2168-
dc.description.abstractA phenyl-selenium-substituted coumarin probe was synthesized for the purpose of achieving highly selective and extremely rapid detection of glutathione (GSH) over cysteine (Cys)/homocysteine (Hcy) without background fluorescence. The fluorescence intensity of the probe with GSH shows a ∼100-fold fluorescent enhancement compared with the signal generated for other closely related amino acids, including Cys and Hcy. Importantly, the substitution reaction with the sulfhydryl group of GSH at the 4-position of the probe, which is doubly-activated by two carbonyl groups, occurs extremely fast, showing subsecond maximum fluorescence intensity attainment; equilibrium was reached within 100 ms (UV-vis). The probe selectivity for GSH was confirmed in Hep3B cells by confocal microscopy imaging. © 2015 Royal Society of Chemistry-
dc.description.uri1-
dc.language영어-
dc.publisherROYAL SOC CHEMISTRY-
dc.titleExceptional time response, stability and selectivity in doubly-activated phenyl selenium-based glutathione-selective platform-
dc.typeArticle-
dc.type.rimsART-
dc.identifier.wosid000361212000010-
dc.identifier.scopusid2-s2.0-84941636053-
dc.identifier.rimsid21308ko
dc.date.tcdate2018-10-01-
dc.contributor.affiliatedAuthorYoungsam Kim-
dc.contributor.affiliatedAuthorSandip V. Mulay-
dc.contributor.affiliatedAuthorDavid G. Churchill-
dc.identifier.doi10.1039/c5sc02090e-
dc.identifier.bibliographicCitationCHEMICAL SCIENCE, v.6, no.10, pp.5435 - 5439-
dc.citation.titleCHEMICAL SCIENCE-
dc.citation.volume6-
dc.citation.number10-
dc.citation.startPage5435-
dc.citation.endPage5439-
dc.date.scptcdate2018-10-01-
dc.description.wostc39-
dc.description.scptc41-
dc.description.journalClass1-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
Appears in Collections:
Center for Catalytic Hydrocarbon Functionalizations(분자활성 촉매반응 연구단) > 1. Journal Papers (저널논문)
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