IL-1 beta in eosinophil-mediated small intestinal homeostasis and IgA production
DC Field | Value | Language |
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dc.contributor.author | Y Jung | - |
dc.contributor.author | T Wen | - |
dc.contributor.author | MK Mingler | - |
dc.contributor.author | JM Caldwell | - |
dc.contributor.author | YH Wang | - |
dc.contributor.author | DD Chaplin | - |
dc.contributor.author | EH Lee | - |
dc.contributor.author | MH Jang | - |
dc.contributor.author | SY Woo | - |
dc.contributor.author | JY Seoh | - |
dc.contributor.author | M Miyasaka | - |
dc.contributor.author | ME Rothenberg | - |
dc.date.available | 2016-01-07T09:12:27Z | - |
dc.date.created | 2015-07-20 | - |
dc.date.issued | 2015-07 | - |
dc.identifier.issn | 1933-0219 | - |
dc.identifier.uri | https://pr.ibs.re.kr/handle/8788114/1968 | - |
dc.description.abstract | Eosinophils are multifunctional leukocytes that reside in the gastrointestinal (GI) lamina propria, where their basal function remains largely unexplored. In this study, by examining mice with a selective deficiency of systemic eosinophils (by lineage ablation) or GI eosinophils (eotaxin-1/2 double deficient orCC chemokine receptor 3 deficient), we show that eosinophils support immunoglobulin A (IgA) class switching, maintain intestinal mucus secretions, affect intestinal microbial composition, and promote the development of Peyer's patches. Eosinophil-deficient mice showed reduced expression of mediators of secretory IgA production, including intestinal interleukin 1 beta (IL-1 beta), inducible nitric oxide synthase, lymphotoxin (LT) alpha, and LT-beta, and reduced levels of retinoic acid-related orphan receptor gamma t-positive (ROR-gamma t(+)) innate lymphoid cells (ILCs), while maintaining normal levels of APRIL (a proliferation-inducing ligand), BAFF (B cell-activating factor of the tumor necrosis factor family), and TGF-beta (transforming growth factor beta). GI eosinophils expressed a relatively high level of IL-1 beta, and IL-1 beta-deficient mice manifested the altered gene expression profiles observed in eosinophil-deficient mice and decreased levels of IgA(+) cells and ROR-gamma t(+) ILCs. On the basis of these collective data, we propose that eosinophils are required for homeostatic intestinal immune responses including IgA production and that their affect is mediated via IL-1 beta in the small intestine | - |
dc.description.uri | 1 | - |
dc.language | 영어 | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.title | IL-1 beta in eosinophil-mediated small intestinal homeostasis and IgA production | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.identifier.wosid | 000356865700021 | - |
dc.identifier.scopusid | 2-s2.0-84928896887 | - |
dc.identifier.rimsid | 20617 | ko |
dc.date.tcdate | 2018-10-01 | - |
dc.contributor.affiliatedAuthor | MH Jang | - |
dc.identifier.doi | 10.1038/mi.2014.123 | - |
dc.identifier.bibliographicCitation | MUCOSAL IMMUNOLOGY, v.8, no.4, pp.930 - 942 | - |
dc.citation.title | MUCOSAL IMMUNOLOGY | - |
dc.citation.volume | 8 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 930 | - |
dc.citation.endPage | 942 | - |
dc.date.scptcdate | 2018-10-01 | - |
dc.description.wostc | 41 | - |
dc.description.scptc | 45 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | INNATE LYMPHOID-CELLS | - |
dc.subject.keywordPlus | ORAL TOLERANCE | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | TGF-BETA | - |
dc.subject.keywordPlus | DENDRITIC CELLS | - |
dc.subject.keywordPlus | LAMINA PROPRIA | - |
dc.subject.keywordPlus | GASTROINTESTINAL EOSINOPHILS | - |
dc.subject.keywordPlus | SECRETORY IGA | - |
dc.subject.keywordPlus | IMMUNE-SYSTEM | - |
dc.subject.keywordPlus | GUT | - |