Synthesis, Characterization, and Biological Evaluation of Oxadiazole Derivatives Bearing 5-Phenyl-tetrazole as Osteoclast Differentiation Inhibitors
Cited 0 time in
Cited 0 time in
1,014 Viewed
167 Downloaded
-
Title
- Synthesis, Characterization, and Biological Evaluation of Oxadiazole Derivatives Bearing 5-Phenyl-tetrazole as Osteoclast Differentiation Inhibitors
-
Author(s)
- Moon, SH; Muhammad Latif; Qasim, M; Choi, SW; Lee, JY; Byun, BJ; Saeed, A; Kim, SH
-
Subject
- Bone, ; Osteoclastogenesis, ; Oxadiazole, ; Tetrazole
-
Publication Date
- 2015-09
-
Journal
- BULLETIN OF THE KOREAN CHEMICAL SOCIETY, v.36, no.9, pp.2247 - 2253
-
Publisher
- WILEY-V C H VERLAG GMBH
-
Abstract
- Novel oxadiazoles bearing 5-phenyl-tetrazole (5a-k) were designed and efficiently synthesized by treating 2-(5-phenyl-2H-tetrazole-2-yl)acetohydrazide (4) with aromatic carboxylic acids in POCl3 , and their in vitro anti-osteoclastogenic activities were evaluated. In the cell-based osteoclast differentiation model, all compounds (5a-k) inhibited the formation of osteoclasts. In addition, the potential target molecules of compound 5 analogs were predicted with their chemical substructures via a web-based interface, and some of them were found to be related to osteoclast differentiation. Consequently, the scaffold containing oxadiazole-tetrazole in a single molecule and their analogs are of potential use in the design of novel anti-osteoclastogenic therapeutics
-
URI
- https://pr.ibs.re.kr/handle/8788114/1907
-
DOI
- 10.1002/bkcs.10436
-
ISSN
- 0253-2964
-
Appears in Collections:
- Center for Catalytic Hydrocarbon Functionalizations(분자활성 촉매반응 연구단) > 1. Journal Papers (저널논문)
- Files in This Item:
-
Synthesis, Characterization, and Biological Evaluation.pdfDownload
-
- Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.