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Muhammad Latif
분자활성 촉매반응 연구단
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Synthesis, Characterization, and Biological Evaluation of Oxadiazole Derivatives Bearing 5-Phenyl-tetrazole as Osteoclast Differentiation Inhibitors

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Title
Synthesis, Characterization, and Biological Evaluation of Oxadiazole Derivatives Bearing 5-Phenyl-tetrazole as Osteoclast Differentiation Inhibitors
Author(s)
Moon, SH; Muhammad Latif; Qasim, M; Choi, SW; Lee, JY; Byun, BJ; Saeed, A; Kim, SH
Publication Date
2015-09
Journal
BULLETIN OF THE KOREAN CHEMICAL SOCIETY, v.36, no.9, pp.2247 - 2253
Publisher
WILEY-V C H VERLAG GMBH
Abstract
Novel oxadiazoles bearing 5-phenyl-tetrazole (5a-k) were designed and efficiently synthesized by treating 2-(5-phenyl-2H-tetrazole-2-yl)acetohydrazide (4) with aromatic carboxylic acids in POCl3 , and their in vitro anti-osteoclastogenic activities were evaluated. In the cell-based osteoclast differentiation model, all compounds (5a-k) inhibited the formation of osteoclasts. In addition, the potential target molecules of compound 5 analogs were predicted with their chemical substructures via a web-based interface, and some of them were found to be related to osteoclast differentiation. Consequently, the scaffold containing oxadiazole-tetrazole in a single molecule and their analogs are of potential use in the design of novel anti-osteoclastogenic therapeutics
URI
https://pr.ibs.re.kr/handle/8788114/1907
ISSN
0253-2964
Appears in Collections:
Center for Catalytic Hydrocarbon Functionalizations(분자활성 촉매반응 연구단) > Journal Papers (저널논문)
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