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뇌과학이미징연구단
뇌과학 이미징 연구단
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dNP2 is a blood-brain barrier-permeable peptide enabling ctCTLA-4 protein delivery to ameliorate experimental autoimmune encephalomyelitis

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dc.contributor.authorLim, S.ko
dc.contributor.authorKim, W.-J.ko
dc.contributor.authorKim, Y.-H.ko
dc.contributor.authorSohee Leeko
dc.contributor.authorKoo, J.-H.ko
dc.contributor.authorLee, J.-A.ko
dc.contributor.authorYoon, H.ko
dc.contributor.authorKim, D.-H.ko
dc.contributor.authorPark, H.-J.ko
dc.contributor.authorKim, H.-M.ko
dc.contributor.authorLee, H.-G.ko
dc.contributor.authorYun Kim, J.ko
dc.contributor.authorLee, J.-U.ko
dc.contributor.authorHun Shin, J.ko
dc.contributor.authorKyun Kim, L.ko
dc.contributor.authorDoh, J.ko
dc.contributor.authorHongtae Kimko
dc.contributor.authorLee, S.-K.ko
dc.contributor.authorBothwell, A.L.M.ko
dc.contributor.authorMinah Suhko
dc.contributor.authorJe-Min Choiko
dc.date.available2016-01-07T09:11:12Z-
dc.date.created2015-10-06ko
dc.date.issued201509ko
dc.identifier.issn2041-1723ko
dc.identifier.urihttp://pr.ibs.re.kr/handle/8788114/1901ko
dc.description.abstractCentral nervous system (CNS)-infiltrating effector T cells play critical roles in the development and progression of multiple sclerosis (MS). However, current drugs for MS are very limited due to the difficulty of delivering drugs into the CNS. Here we identify a cell-permeable peptide, dNP2, which efficiently delivers proteins into mouse and human T cells, as well as various tissues. Moreover, it enters the brain tissue and resident cells through blood vessels by penetrating the tightly organized blood-brain barrier. The dNP2-conjugated cytoplasmic domain of cytotoxic T-lymphocyte antigen 4 (dNP2-ctCTLA-4) negatively regulates activated T cells and shows inhibitory effects on experimental autoimmune encephalomyelitis in both preventive and therapeutic mouse models, resulting in the reduction of demyelination and CNS-infiltrating T helper 1 and T helper 17 cells. Thus, this study demonstrates that dNP2 is a blood-brain barrier-permeable peptide and dNP2-ctCTLA-4 could be an effective agent for treating CNS inflammatory diseases such as MS. © 2015 Macmillan Publishers Limited. All rights reservedko
dc.languageENGko
dc.publisherNATURE PUBLISHING GROUPko
dc.titledNP2 is a blood-brain barrier-permeable peptide enabling ctCTLA-4 protein delivery to ameliorate experimental autoimmune encephalomyelitisko
dc.typeARTICLEko
dc.type.rimsAko
dc.identifier.wosid000363017500015ko
dc.identifier.scopusid2-s2.0-84941758039ko
dc.identifier.pid362null
dc.description.wostc17-
dc.date.scptcdate2018-10-01-
dc.identifier.doi10.1038/ncomms9244ko
dc.identifier.bibliographicCitationNATURE COMMUNICATIONS, v.6, no., pp.8244 -ko
dc.date.tcdate2018-10-01-
dc.description.scptc27-
dc.type.docTypeArticle-
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Center for Neuroscience Imaging Research (뇌과학 이미징 연구단) > Journal Papers (저널논문)
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