IRSp53/BAIAP2 in dendritic spine development, NMDA receptor regulation, and psychiatric disorders

Cited 9 time in webofscience Cited 0 time in scopus
446 Viewed 24 Downloaded
Title
IRSp53/BAIAP2 in dendritic spine development, NMDA receptor regulation, and psychiatric disorders
Author(s)
Jaeseung Kang; Haram Park; Eunjoon Kim
Publication Date
2016-01
Journal
NEUROPHARMACOLOGY, v.100, no., pp.27 - 39
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Abstract
IRSp53 (also known as BAIAP2) is a multi-domain scaffolding and adaptor protein that has been implicated in the regulation of membrane and actin dynamics at subcellular structures, including filopodia and lamellipodia. Accumulating evidence indicates that IRSp53 is an abundant component of the postsynaptic density at excitatory synapses and an important regulator of actin-rich dendritic spines. In addition, IRSp53 has been implicated in diverse psychiatric disorders, including autism spectrum disorders, schizophrenia, and attention deficit/hyperactivity disorder. Mice lacking IRSp53 display enhanced NMDA (N-methyl-d-aspartate) receptor function accompanied by social and cognitive deficits, which are reversed by pharmacological suppression of NMDA receptor function. These results suggest the hypothesis that defective actin/membrane modulation in IRSp53-deficient dendritic spines may lead to social and cognitive deficits through NMDA receptor dysfunction. This article is part of the Special Issue entitled 'Synaptopathy - from Biology to Therapy'. © 2015 The Authors. All rights reserved
URI
https://pr.ibs.re.kr/handle/8788114/1820
ISSN
0028-3908
Appears in Collections:
Center for Synaptic Brain Dysfunctions(시냅스 뇌질환 연구단) > Journal Papers (저널논문)
Files in This Item:
2015_122.pdfDownload

qrcode

  • facebook

    twitter

  • Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse