Deficiency of Capicua disrupts bile acid homeostasis
DC Field | Value | Language |
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dc.contributor.author | Eunjeong Kim | - |
dc.contributor.author | Sungjun Park | - |
dc.contributor.author | Nahyun Choi | - |
dc.contributor.author | Jieon Lee | - |
dc.contributor.author | Jeehyun Yoe | - |
dc.contributor.author | Soeun Kim | - |
dc.contributor.author | Hoe-Yune Jung | - |
dc.contributor.author | Kyong-Tai Kim | - |
dc.contributor.author | Hyojin Kang | - |
dc.contributor.author | John D. Fryer | - |
dc.contributor.author | Huda Y. Zoghbi | - |
dc.contributor.author | Daehee Hwang | - |
dc.contributor.author | Yoontae Lee | - |
dc.date.available | 2015-06-11T05:41:43Z | - |
dc.date.created | 2015-06-03 | ko |
dc.date.issued | 2015-02 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | https://pr.ibs.re.kr/handle/8788114/1634 | - |
dc.description.abstract | Capicua (CIC) has been implicated in pathogenesis of spinocerebellar ataxia type 1 and cancer in mammals; however, the in vivo physiological functions of CIC remain largely unknown. Here we show that Cic hypomorphic (Cic-L-/-) mice have impaired bile acid (BA) homeostasis associated with induction of proinflammatory cytokines. We discovered that several drug metabolism and BA transporter genes were down-regulated in Cic-L-/- liver, and that BA was increased in the liver and serum whereas bile was decreased within the gallbladder of Cic-L-/- mice. We also found that levels of proinflammatory cytokine genes were up-regulated in Cic-L-/- liver. Consistent with this finding, levels of hepatic transcriptional regulators, such as hepatic nuclear factor 1 alpha (HNF1a), CCAAT/enhancer-binding protein beta (C/EBPb), forkhead box protein A2 (FOXA2), and retinoid X receptor alpha (RXRa), were markedly decreased in Cic-L-/- mice. Moreover, induction of tumor necrosis factor alpha (Tnfa) expression and decrease in the levels of FOXA2, C/EBPb, and RXRa were found in Cic-L-/- liver before BA was accumulated, suggesting that inflammation might be the cause for the cholestasis in Cic-L-/- mice. Our findings indicate that CIC is a critical regulator of BA homeostasis, and that its dysfunction might be associated with chronic liver disease and metabolic disorders. | - |
dc.description.uri | 1 | - |
dc.language | 영어 | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.subject | Constitutive Adnrostane Receptor | - |
dc.subject | Enriched Transcription Factors | - |
dc.subject | Binding-Protein-Beta | - |
dc.subject | Pregnane-X-Receptor | - |
dc.subject | Induced Cholestasis | - |
dc.subject | Repressor Capicua | - |
dc.subject | Liver | - |
dc.subject | Gene | - |
dc.subject | Mice | - |
dc.subject | Alpha | - |
dc.title | Deficiency of Capicua disrupts bile acid homeostasis | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.identifier.wosid | 000348833600001 | - |
dc.identifier.scopusid | 2-s2.0-84943376843 | - |
dc.identifier.rimsid | 19773 | ko |
dc.date.tcdate | 2018-10-01 | - |
dc.contributor.affiliatedAuthor | Daehee Hwang | - |
dc.identifier.doi | 10.1038/srep08272 | - |
dc.identifier.bibliographicCitation | SCIENTIFIC REPORTS, v.5, pp.8272 | - |
dc.citation.title | SCIENTIFIC REPORTS | - |
dc.citation.volume | 5 | - |
dc.citation.startPage | 8272 | - |
dc.date.scptcdate | 2018-10-01 | - |
dc.description.wostc | 8 | - |
dc.description.scptc | 10 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |