Neural Correlates of Interval Timing in Rodent Prefrontal Cortex

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Title
Neural Correlates of Interval Timing in Rodent Prefrontal Cortex
Author(s)
Jieun Kim; Jeong-Wook Ghim; Ji Hyun Lee; Min Whan Jung
Publication Date
2013-08
Journal
JOURNAL OF NEUROSCIENCE, v.33, no.34, pp.13834 - 13847
Publisher
SOC NEUROSCIENCE
Abstract
Time interval estimation is involved in numerous behavioral processes, but its underlying neural mechanisms remain unclear. In particular, it has been controversial whether time is encoded on a linear or logarithmic scale. Based on our previous finding that inactivation of the medial prefrontal cortex (mPFC) profoundly impairs rat’s ability to discriminate time intervals, we investigated how the mPFC processes temporal information by examining activity of mPFC neurons in rats performing a temporal bisection task. Many mPFC neurons conveyed temporal information based on monotonically changing activity profiles over time with negative accelerations, so that their activity profiles were better described by logarithmic than linear functions. Moreover, the precision of time-interval discrimination based on neural activity was lowered in proportion to the elapse of time, but without proportional increase in neural variability, which is well accounted for by logarithmic, but not by linear functions. As a population, mPFC neurons conveyed precise information about the elapse of time with their activity tightly correlated with the animal’s choice of target. These results suggest that the mPFC might be part of an internal clock in charge of controlling interval-timing behavior, and that linearly changing neuronal activity on a logarithmic time scale might be one way of representing the elapse of time in the brain.
URI
https://pr.ibs.re.kr/handle/8788114/1581
ISSN
0270-6474
Appears in Collections:
Center for Synaptic Brain Dysfunctions(시냅스 뇌질환 연구단) > Journal Papers (저널논문)
Files in This Item:
2013-08-21-Journal of Neuroscience-Neural correlates.pdfDownload

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