Unique Features of Naive CD8+ T Cell Activation by IL-2
DC Field | Value | Language |
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dc.contributor.author | Jae Ho Cho | - |
dc.contributor.author | Hee-Ok Kim | - |
dc.contributor.author | Kyu-Sik Kim | - |
dc.contributor.author | Deok-Hwan Yang | - |
dc.contributor.author | Charles D. Surh | - |
dc.contributor.author | Jonathan Sprent | - |
dc.date.available | 2015-04-21T09:32:35Z | - |
dc.date.created | 2014-08-11 | - |
dc.date.issued | 2013-12 | - |
dc.identifier.issn | 0022-1767 | - |
dc.identifier.uri | https://pr.ibs.re.kr/handle/8788114/1558 | - |
dc.description.abstract | IL-2 has a pervasive influence on the immune system and dictates the survival and differentiation of multiple T cell subsets, including CD4 regulatory T cells, CD4 Th cells, and CD8 memory cells. IL-2 is synthesized by T cells during the early stages of the immune response and promotes T cell expansion and effector cell generation after initial activation via TCR signaling. Based on studies with activated T cell lines maintained in vitro, IL-2 is known to activate multiple signaling pathways that show considerable overlap with the pathways elicited via the TCR. In this paper, we have examined IL-2 signaling under TCR-independent conditions, namely by culturing purified resting naive CD8 T cells with IL-2 in the absence of Ag or APC. Under these conditions, we show in this study that IL-2 elicits a unique pattern of signaling associated with strong lymphocyte-specific protein tyrosine kinase/JAK3- dependent activation of the PI3K/AKT pathway with little or no involvement of STAT5, NF-kB, or the calcineurin/NFAT pathways. Such signaling induces marked proliferation associated with rapid and selective expression of eomesodermin but not T-bet and differentiation into long-lived central memory cells after adoptive transfer. The Journal of Immunology, 2013, 191: 5559–5573. | - |
dc.description.uri | 1 | - |
dc.language | 영어 | - |
dc.publisher | AMER ASSOC IMMUNOLOGISTS | - |
dc.title | Unique Features of Naive CD8+ T Cell Activation by IL-2 | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.identifier.wosid | 000327180600023 | - |
dc.identifier.scopusid | 2-s2.0-84888315192 | - |
dc.identifier.rimsid | 248 | ko |
dc.date.tcdate | 2018-10-01 | - |
dc.contributor.affiliatedAuthor | Jae Ho Cho | - |
dc.contributor.affiliatedAuthor | Charles D. Surh | - |
dc.contributor.affiliatedAuthor | Jonathan Sprent | - |
dc.identifier.doi | 10.4049/jimmunol.1302293 | - |
dc.identifier.bibliographicCitation | JOURNAL OF IMMUNOLOGY, v.191, no.11, pp.5559 - 5573 | - |
dc.citation.title | JOURNAL OF IMMUNOLOGY | - |
dc.citation.volume | 191 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 5559 | - |
dc.citation.endPage | 5573 | - |
dc.date.scptcdate | 2018-10-01 | - |
dc.description.wostc | 16 | - |
dc.description.scptc | 17 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |