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인지및사회성연구단
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Light-inducible receptor tyrosine kinases that regulate neurotrophin signalling

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dc.contributor.authorKi-Young Chang-
dc.contributor.authorDoyeon Woo-
dc.contributor.authorHyunjin Jung-
dc.contributor.authorSangkyu Lee-
dc.contributor.authorSungsoo Kim-
dc.contributor.authorJoungha Won-
dc.contributor.authorTaeyoon Kyung-
dc.contributor.authorHyerim Park-
dc.contributor.authorNury, Kim-
dc.contributor.authorHee Won Yang-
dc.contributor.authorJae-Yong Park-
dc.contributor.authorEun Mi Hwang-
dc.contributor.authorDaesoo Kim-
dc.contributor.authorWon Do Heo-
dc.date.available2015-04-21T09:14:57Z-
dc.date.created2014-08-11-
dc.date.issued2014-06-
dc.identifier.issn2041-1723-
dc.identifier.urihttps://pr.ibs.re.kr/handle/8788114/1506-
dc.description.abstractReceptor tyrosine kinases (RTKs) are a family of cell-surface receptors that have a key role in regulating critical cellular processes. Here, to understand and precisely control RTK signalling, we report the development of a genetically encoded, photoactivatable Trk (tropomyosin-related kinase) family of RTKs using a light-responsive module based on Arabidopsis thaliana cryptochrome 2. Blue-light stimulation (488-nm) of mammalian cells harbouring these receptors robustly upregulates canonical Trk signalling. A single light stimulus triggers transient signalling activation, which is reversibly tuned by repetitive delivery of blue-light pulses. In addition, the light-provoked process is induced in a spatially restricted and cell-specific manner. A prolonged patterned illumination causes sustained activation of extracellular signal-regulated kinase and promotes neurite outgrowth in a neuronal cell line, and induces filopodia formation in rat hippocampal neurons. These light-controllable receptors are expected to create experimental opportunities to spatiotemporally manipulate many biological processes both in vitro and in vivo. © 2014 Macmillan Publishers Limited.-
dc.description.uri1-
dc.language영어-
dc.publisherNATURE PUBLISHING GROUP-
dc.titleLight-inducible receptor tyrosine kinases that regulate neurotrophin signalling-
dc.typeArticle-
dc.type.rimsART-
dc.identifier.wosid000338838000001-
dc.identifier.scopusid2-s2.0-84901992638-
dc.identifier.rimsid15ko
dc.date.tcdate2018-10-01-
dc.contributor.affiliatedAuthorKi-Young Chang-
dc.contributor.affiliatedAuthorSangkyu Lee-
dc.contributor.affiliatedAuthorNury, Kim-
dc.contributor.affiliatedAuthorWon Do Heo-
dc.identifier.doi10.1038/ncomms5057-
dc.identifier.bibliographicCitationNATURE COMMUNICATIONS, v.5, pp.4057-
dc.citation.titleNATURE COMMUNICATIONS-
dc.citation.volume5-
dc.citation.startPage4057-
dc.date.scptcdate2018-10-01-
dc.description.wostc39-
dc.description.scptc39-
dc.description.journalClass1-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
Appears in Collections:
Center for Cognition and Sociality(인지 및 사회성 연구단) > 1. Journal Papers (저널논문)
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