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Noisy Delay Denoises Biochemical Oscillators

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Title
Noisy Delay Denoises Biochemical Oscillators
Author(s)
Yun Min Song; Campbell, Sean; Shiau, Liejune; Jae Kyoung Kim; Ott, William
Publication Date
2024-02
Journal
Physical Review Letters, v.132, no.7
Publisher
American Physical Society
Abstract
Genetic oscillations are generated by delayed transcriptional negative feedback loops, wherein repressor proteins inhibit their own synthesis after a temporal production delay. This delay is distributed because it arises from a sequence of noisy processes, including transcription, translocation, translation, and folding. Because the delay determines repression timing and, therefore, oscillation period, it has been commonly believed that delay noise weakens oscillatory dynamics. Here, we demonstrate that noisy delay can surprisingly denoise genetic oscillators. Specifically, moderate delay noise improves the signal-to-noise ratio and sharpens oscillation peaks, all without impacting period and amplitude. We show that this denoising phenomenon occurs in a variety of well-studied genetic oscillators, and we use queueing theory to uncover the universal mechanisms that produce it. © 2024 American Physical Society.
URI
https://pr.ibs.re.kr/handle/8788114/15021
DOI
10.1103/PhysRevLett.132.078402
ISSN
0031-9007
Appears in Collections:
Pioneer Research Center for Mathematical and Computational Sciences(수리 및 계산과학 연구단) > Biomedical Mathematics Group(의생명 수학 그룹) > 1. Journal Papers (저널논문)
Pioneer Research Center for Mathematical and Computational Sciences(수리 및 계산과학 연구단) > 1. Journal Papers (저널논문)
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