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Diverging asymmetry of intrinsic functional organization in autism

DC Field Value Language
dc.contributor.authorWan, Bin-
dc.contributor.authorSeok-Jun Hong-
dc.contributor.authorBethlehem, Richard A. I.-
dc.contributor.authorFloris, Dorothea L.-
dc.contributor.authorBernhardt, Boris C.-
dc.contributor.authorValk, Sofie L.-
dc.date.accessioned2024-02-06T22:02:42Z-
dc.date.available2024-02-06T22:02:42Z-
dc.date.created2023-08-28-
dc.date.issued2023-10-
dc.identifier.issn1359-4184-
dc.identifier.urihttps://pr.ibs.re.kr/handle/8788114/14783-
dc.description.abstractAutism is a neurodevelopmental condition involving atypical sensory-perceptual functions together with language and socio-cognitive deficits. Previous work has reported subtle alterations in the asymmetry of brain structure and reduced laterality of functional activation in individuals with autism relative to non-autistic individuals (NAI). However, whether functional asymmetries show altered intrinsic systematic organization in autism remains unclear. Here, we examined inter- and intra-hemispheric asymmetry of intrinsic functional gradients capturing connectome organization along three axes, stretching between sensory-default, somatomotor-visual, and default-multiple demand networks, to study system-level hemispheric imbalances in autism. We observed decreased leftward functional asymmetry of language network organization in individuals with autism, relative to NAI. Whereas language network asymmetry varied across age groups in NAI, this was not the case in autism, suggesting atypical functional laterality in autism may result from altered developmental trajectories. Finally, we observed that intra- but not inter-hemispheric features were predictive of the severity of autistic traits. Our findings illustrate how regional and patterned functional lateralization is altered in autism at the system level. Such differences may be rooted in atypical developmental trajectories of functional organization asymmetry in autism.-
dc.language영어-
dc.publisherNature Publishing Group-
dc.titleDiverging asymmetry of intrinsic functional organization in autism-
dc.typeArticle-
dc.type.rimsART-
dc.identifier.wosid001049135700001-
dc.identifier.scopusid2-s2.0-85168086591-
dc.identifier.rimsid81584-
dc.contributor.affiliatedAuthorSeok-Jun Hong-
dc.identifier.doi10.1038/s41380-023-02220-x-
dc.identifier.bibliographicCitationMolecular Psychiatry, v.28, pp.4331 - 4341-
dc.relation.isPartOfMolecular Psychiatry-
dc.citation.titleMolecular Psychiatry-
dc.citation.volume28-
dc.citation.startPage4331-
dc.citation.endPage4341-
dc.description.journalClass1-
dc.description.journalClass1-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalWebOfScienceCategoryBiochemistry & Molecular Biology-
dc.relation.journalWebOfScienceCategoryNeurosciences-
dc.relation.journalWebOfScienceCategoryPsychiatry-
dc.subject.keywordPlusSPECTRUM DISORDER-
dc.subject.keywordPlusCORPUS-CALLOSUM-
dc.subject.keywordPlusLANGUAGE LATERALIZATION-
dc.subject.keywordPlusSEX-DIFFERENCES-
dc.subject.keywordPlusCHILDREN-
dc.subject.keywordPlusHERITABILITY-
dc.subject.keywordPlusADOLESCENTS-
dc.subject.keywordPlusCOMMUNICATION-
dc.subject.keywordPlusCONNECTIVITY-
dc.subject.keywordPlusPREVALENCE-
Appears in Collections:
Center for Neuroscience Imaging Research (뇌과학 이미징 연구단) > 1. Journal Papers (저널논문)
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