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분자활성촉매반응연구단
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Enantioselective Aziridination of Unactivated Terminal Alkenes Using a Planar Chiral Rh(III) Indenyl Catalyst

DC Field Value Language
dc.contributor.authorGross, Patrick-
dc.contributor.authorHoyoung Im-
dc.contributor.authorLaws, David-
dc.contributor.authorBohyun Park-
dc.contributor.authorMu-Hyun Baik-
dc.contributor.authorBlakey, Simon B.-
dc.date.accessioned2024-02-02T22:00:13Z-
dc.date.available2024-02-02T22:00:13Z-
dc.date.created2024-01-22-
dc.date.issued2024-01-
dc.identifier.issn0002-7863-
dc.identifier.urihttps://pr.ibs.re.kr/handle/8788114/14767-
dc.description.abstractChiral aziridines are important structural motifs found in natural products and various target molecules. They serve as versatile building blocks for the synthesis of chiral amines. While advances in catalyst design have enabled robust methods for enantioselective aziridination of activated olefins, simple and abundant alkyl-substituted olefins pose a significant challenge. In this work, we introduce a novel approach utilizing a planar chiral rhodium indenyl catalyst to facilitate the enantioselective aziridination of unactivated alkenes. This transformation exhibits a remarkable degree of functional group tolerance and displays excellent chemoselectivity favoring unactivated alkenes over their activated counterparts, delivering a wide range of enantioenriched high-value chiral aziridines. Computational studies unveil a stepwise aziridination mechanism in which alkene migratory insertion plays a central role. This process results in the formation of a strained four-membered metallacycle and serves as both the enantio- and rate-determining steps in the overall reaction. © 2024 The Authors. Published by American Chemical Society.-
dc.language영어-
dc.publisherAmerican Chemical Society-
dc.titleEnantioselective Aziridination of Unactivated Terminal Alkenes Using a Planar Chiral Rh(III) Indenyl Catalyst-
dc.typeArticle-
dc.type.rimsART-
dc.identifier.wosid001144584900001-
dc.identifier.scopusid2-s2.0-85182014272-
dc.identifier.rimsid82417-
dc.contributor.affiliatedAuthorHoyoung Im-
dc.contributor.affiliatedAuthorBohyun Park-
dc.contributor.affiliatedAuthorMu-Hyun Baik-
dc.identifier.doi10.1021/jacs.3c10637-
dc.identifier.bibliographicCitationJournal of the American Chemical Society, v.146, no.2, pp.1447 - 1454-
dc.relation.isPartOfJournal of the American Chemical Society-
dc.citation.titleJournal of the American Chemical Society-
dc.citation.volume146-
dc.citation.number2-
dc.citation.startPage1447-
dc.citation.endPage1454-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.description.journalClass1-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaChemistry-
dc.relation.journalWebOfScienceCategoryChemistry, Multidisciplinary-
dc.subject.keywordPlusASYMMETRIC AZIRIDINATION-
dc.subject.keywordPlusLIGAND-
dc.subject.keywordPlusDEPROTECTION-
dc.subject.keywordPlusCHEMISTRY-
dc.subject.keywordPlusHYDROGEN-
dc.subject.keywordPlusCOMPLEX-
dc.subject.keywordPlusOLEFINS-
Appears in Collections:
Center for Catalytic Hydrocarbon Functionalizations(분자활성 촉매반응 연구단) > 1. Journal Papers (저널논문)
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