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Sensory cortical ensembles exhibit differential coupling to ripples in distinct hippocampal subregions

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Title
Sensory cortical ensembles exhibit differential coupling to ripples in distinct hippocampal subregions
Author(s)
Huijeong Jeong; Namboodiri, Vijay Mohan K.; Min Whan Jung; Andermann, Mark L.
Publication Date
2023-12
Journal
Current Biology, v.33, no.23, pp.5185 - 5198
Publisher
Cell Press
Abstract
Cortical neurons activated during recent experiences often reactivate with dorsal hippocampal CA1 ripples during subsequent rest. Less is known about cortical interactions with intermediate hippocampal CA1, whose connectivity, functions, and ripple events differ from dorsal CA1. We identified three clusters of putative excitatory neurons in mouse visual cortex that are preferentially excited together with either dorsal or intermediate CA1 ripples or suppressed before both ripples. Neurons in each cluster were evenly distributed across primary and higher visual cortices and co-active even in the absence of ripples. These ensembles exhibited similar visual responses but different coupling to thalamus and pupil-indexed arousal. We observed a consistent activity sequence preceding and predicting ripples: (1) suppression of ripple-suppressed cortical neurons, (2) thalamic silence, and (3) activation of intermediate CA1-ripple-activated cortical neurons. We propose that coordinated dynamics of these ensembles relay visual experiences to distinct hippocampal subregions for incorporation into different cognitive maps. © 2023 Elsevier Inc.
URI
https://pr.ibs.re.kr/handle/8788114/14707
DOI
10.1016/j.cub.2023.10.073
ISSN
0960-9822
Appears in Collections:
Center for Synaptic Brain Dysfunctions(시냅스 뇌질환 연구단) > 1. Journal Papers (저널논문)
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