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Changseok, Lee
분자활성 촉매반응 연구단
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NiH-catalyzed C-N bond formation: insights and advancements in hydroamination of unsaturated hydrocarbons

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Title
NiH-catalyzed C-N bond formation: insights and advancements in hydroamination of unsaturated hydrocarbons
Author(s)
Changseok Lee; Hyung-Joon Kang; Sungwoo Hong
Publication Date
2024-01
Journal
Chemical Science, v.2, no.2, pp.442 - 457
Publisher
Royal Society of Chemistry
Abstract
The formation of C-N bonds is a fundamental aspect of organic synthesis, and hydroamination has emerged as a pivotal strategy for the synthesis of essential amine derivatives. In recent years, there has been a surge of interest in metal hydride-catalyzed hydroamination reactions of common alkenes and alkynes. This method avoids the need for stoichiometric organometallic reagents and overcomes problems associated with specific organometallic compounds that may impact functional group compatibility. Notably, recent developments have brought to the forefront olefinic hydroamination and hydroamidation reactions facilitated by nickel hydride (NiH) catalysis. The inclusion of suitable chiral ligands has paved the way for the realization of asymmetric hydroamination reactions in the realm of olefins. This review aims to provide an in-depth exploration of the latest achievements in C-N bond formation through intermolecular hydroamination catalyzed by nickel hydrides. Leveraging this innovative approach, a diverse range of alkene and alkyne substrates can be efficiently transformed into value-added compounds enriched with C-N bonds. The intricacies of C-N bond formation are succinctly elucidated, offering a concise overview of the underlying reaction mechanisms. It is our aspiration that this comprehensive review will stimulate further progress in NiH-catalytic techniques, fine-tune reaction systems, drive innovation in catalyst design, and foster a deeper understanding of the underlying mechanisms. This review highlights recent progress in NiH-catalyzed hydroamination, focusing on its application to a variety of alkenes and alkynes.
URI
https://pr.ibs.re.kr/handle/8788114/14464
DOI
10.1039/d3sc05589b
ISSN
2041-6520
Appears in Collections:
Center for Catalytic Hydrocarbon Functionalizations(분자활성 촉매반응 연구단) > 1. Journal Papers (저널논문)
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