BROWSE

ITEM VIEW & DOWNLOAD

Caenorhabditis elegans NSE3 homolog (MAGE-1) is involved in genome stability and acts in inter-sister recombination during meiosis

DC Field Value Language
dc.contributor.authorOdiba, Arome Solomon-
dc.contributor.authorLiao, Guiyan-
dc.contributor.authorEzechukwu, Chiemekam Samuel-
dc.contributor.authorZhang, Lanlan-
dc.contributor.authorHong, Ye-
dc.contributor.authorFang, Wenxia-
dc.contributor.authorJin, Cheng-
dc.contributor.authorAnton Gartner-
dc.contributor.authorWang, Bin-
dc.date.accessioned2023-12-29T22:00:48Z-
dc.date.available2023-12-29T22:00:48Z-
dc.date.created2023-11-07-
dc.date.issued2023-10-
dc.identifier.issn0016-6731-
dc.identifier.urihttps://pr.ibs.re.kr/handle/8788114/14430-
dc.description.abstractMelanoma antigen (MAGE) genes encode for a family of proteins that share a common MAGE homology domain. These genes are conserved in eukaryotes and have been linked to a variety of cellular and developmental processes including ubiquitination and oncogenesis in cancer. Current knowledge on the MAGE family of proteins mainly comes from the analysis of yeast and human cell lines, and their functions have not been reported at an organismal level in animals. Caenorhabditis elegans only encodes 1 known MAGE gene member, mage-1 (NSE3 in yeast), forming part of the SMC-5/6 complex. Here, we characterize the role of mage-1/nse-3 in mitosis and meiosis in C. elegans. mage-1/nse-3 has a role in inter-sister recombination repair during meiotic recombination and for preserving chromosomal integrity upon treatment with a variety of DNA-damaging agents. MAGE-1 directly interacts with NSE-1 and NSE-4. In contrast to smc-5, smc-6, and nse-4 mutants which cause the loss of NSE-1 nuclear localization and strong cytoplasmic accumulation, mage-1/nse-3 mutants have a reduced level of NSE-1::GFP, remnant NSE-1::GFP being partially nuclear but largely cytoplasmic. Our data suggest that MAGE-1 is essential for NSE-1 stability and the proper functioning of the SMC-5/6 complex.-
dc.language영어-
dc.publisherGenetics Society of America-
dc.titleCaenorhabditis elegans NSE3 homolog (MAGE-1) is involved in genome stability and acts in inter-sister recombination during meiosis-
dc.typeArticle-
dc.type.rimsART-
dc.identifier.wosid001148042000016-
dc.identifier.scopusid2-s2.0-85174700003-
dc.identifier.rimsid82072-
dc.contributor.affiliatedAuthorAnton Gartner-
dc.identifier.doi10.1093/genetics/iyad149-
dc.identifier.bibliographicCitationGenetics, v.225, no.2-
dc.relation.isPartOfGenetics-
dc.citation.titleGenetics-
dc.citation.volume225-
dc.citation.number2-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.description.journalClass1-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaGenetics & Heredity-
dc.relation.journalWebOfScienceCategoryGenetics & Heredity-
dc.subject.keywordPlusDNA-DAMAGE RESPONSE-
dc.subject.keywordPlusSMC5/6 COMPLEX-
dc.subject.keywordPlusC-ELEGANS-
dc.subject.keywordPlusPROTEIN-
dc.subject.keywordPlusREPAIR-
dc.subject.keywordPlusMAINTENANCE-
dc.subject.keywordPlusSUBUNIT-
dc.subject.keywordPlusFAMILY-
dc.subject.keywordPlusREPLICATION-
dc.subject.keywordPlusRECRUITMENT-
dc.subject.keywordAuthorC. elegans-
dc.subject.keywordAuthorDNA repair-
dc.subject.keywordAuthormage-1-
dc.subject.keywordAuthormeiosis-
dc.subject.keywordAuthormitosis-
dc.subject.keywordAuthorSMC-5/6 complex-
Appears in Collections:
Center for Genomic Integrity(유전체 항상성 연구단) > 1. Journal Papers (저널논문)
Files in This Item:
There are no files associated with this item.

qrcode

  • facebook

    twitter

  • Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse