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Selective ring expansion and C−H functionalization of azulenes

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Title
Selective ring expansion and C−H functionalization of azulenes
Author(s)
Park, Sangjune; Kim, Cheol-Eui; Jinhoon Jeong; Ho Ryu; Maeng, Chanyoung; Dongwook Kim; Mu-Hyun Baik; Lee, Phil Ho
Publication Date
2023-12
Journal
Nature Communications, v.14, no.1
Publisher
Nature Research
Abstract
We report a transition metal-catalyzed ring expansion of azulene that can be contrasted with C–H functionalization. This study represents the first example of the successful ring expansion of azulene using Cu(hfacac)2 (hfacac: hexafluoroacetylacetonate) with a diazo reagent. This result is notable for extending the Buchner reaction, previously limited to benzenoid aromatics, to nonbenzenoid compounds. The chemoselectivity of the reaction can be directed towards C–H functionalization by substituting the Cu catalyst with AgOTf. This approach does not require the addition of phosphine, NHC, or related ligands, and prefunctionalization of azulenes is unnecessary. Furthermore, the method exhibits excellent functional group tolerance, allowing for the synthesis of a wide range of 6,7-bicyclic compounds and C–H functionalized azulenes. We also present a theoretical study that explains the experimental observations, explaining why copper afford the ring expansion product while silver forms the C–H alkylation product.
URI
https://pr.ibs.re.kr/handle/8788114/14372
DOI
10.1038/s41467-023-43200-7
ISSN
2041-1723
Appears in Collections:
Center for Catalytic Hydrocarbon Functionalizations(분자활성 촉매반응 연구단) > 1. Journal Papers (저널논문)
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