BROWSE

Related Scientist

cchf's photo.

cchf
분자활성촉매반응연구단
more info

ITEM VIEW & DOWNLOAD

Iridium Acylnitrenoid-Initiated Biomimetic Cascade Cyclizations: Stereodefined Access to Polycyclic δ-Lactams

DC Field Value Language
dc.contributor.authorTufano, Eleonora-
dc.contributor.authorEuijae Lee-
dc.contributor.authorBarilli, Matteo-
dc.contributor.authorCasali, Emanuele-
dc.contributor.authorOstrek, Andraz-
dc.contributor.authorHoimin Jung-
dc.contributor.authorMorana, Marta-
dc.contributor.authorJihye Kang-
dc.contributor.authorDongwook Kim-
dc.contributor.authorSukbok Chang-
dc.contributor.authorZanoni, Giuseppe-
dc.date.accessioned2023-12-13T22:00:19Z-
dc.date.available2023-12-13T22:00:19Z-
dc.date.created2023-12-05-
dc.date.issued2023-11-
dc.identifier.issn0002-7863-
dc.identifier.urihttps://pr.ibs.re.kr/handle/8788114/14346-
dc.description.abstractRing-fused azacyclic compounds are important building units in the synthesis of biorelevant natural products, pharmaceutical agents, and molecular materials. Herein, we present a new approach to these condensed azacycles by a biomimetic cascade cyclization of arylalkenyl dioxazolones. This cascade reaction was found to proceed with excellent stereoselectivity and a high functional group tolerance. The substrate scope of arylalkenyl dioxazolones turned out to be highly flexible and extendable to additional terminating subunits, such as heteroaryl and alkynyl moieties. This biomimetic cyclization was elucidated to be initiated by an intramolecular transfer of the in situ generated electrophilic Ir-acylnitrenoid to the tethered olefinic double bond, leading to a key N-acylaziridine intermediate, which is in turn reacted with pendant (hetero)-arenes or alkynes in a highly regio- and stereoselective manner to produce ring-fused azacyclic compounds.-
dc.language영어-
dc.publisherAMER CHEMICAL SOC-
dc.titleIridium Acylnitrenoid-Initiated Biomimetic Cascade Cyclizations: Stereodefined Access to Polycyclic δ-Lactams-
dc.typeArticle-
dc.type.rimsART-
dc.identifier.wosid001105556700001-
dc.identifier.scopusid2-s2.0-85178219034-
dc.identifier.rimsid82133-
dc.contributor.affiliatedAuthorEuijae Lee-
dc.contributor.affiliatedAuthorHoimin Jung-
dc.contributor.affiliatedAuthorJihye Kang-
dc.contributor.affiliatedAuthorDongwook Kim-
dc.contributor.affiliatedAuthorSukbok Chang-
dc.identifier.doi10.1021/jacs.3c08331-
dc.identifier.bibliographicCitationJOURNAL OF THE AMERICAN CHEMICAL SOCIETY, v.145, no.45, pp.24724 - 24735-
dc.relation.isPartOfJOURNAL OF THE AMERICAN CHEMICAL SOCIETY-
dc.citation.titleJOURNAL OF THE AMERICAN CHEMICAL SOCIETY-
dc.citation.volume145-
dc.citation.number45-
dc.citation.startPage24724-
dc.citation.endPage24735-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.description.journalClass1-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaChemistry-
dc.relation.journalWebOfScienceCategoryChemistry, Multidisciplinary-
dc.subject.keywordPlusNONCOVALENT INTERACTIONS-
dc.subject.keywordPlusDITERPENOID ALKALOIDS-
dc.subject.keywordPlusPOLYENE CYCLIZATIONS-
dc.subject.keywordPlusHYDROAMINATION-
dc.subject.keywordPlusSUBSTITUENTS-
dc.subject.keywordPlusAMINATION-
dc.subject.keywordPlusC-H AMIDATION-
dc.subject.keywordPlus5-ALPHA-REDUCTASE INHIBITORS-
dc.subject.keywordPlusSTEREOCONTROLLED SYNTHESIS-
dc.subject.keywordPlusSTEREOSELECTIVE-SYNTHESIS-
Appears in Collections:
Center for Catalytic Hydrocarbon Functionalizations(분자활성 촉매반응 연구단) > 1. Journal Papers (저널논문)
Files in This Item:
There are no files associated with this item.

qrcode

  • facebook

    twitter

  • Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse