BROWSE

ITEM VIEW & DOWNLOAD

Corticosteroids reduce pathologic interferon responses by downregulating STAT1 in patients with high-risk COVID-19

DC Field Value Language
dc.contributor.authorJeong, Hyun-Woo-
dc.contributor.authorLee, Jeong Seok-
dc.contributor.authorKo, Jae-Hoon-
dc.contributor.authorHong, Seunghee-
dc.contributor.authorOh, Sang Taek-
dc.contributor.authorChoi, Seongkyun-
dc.contributor.authorPeck, Kyong Ran-
dc.contributor.authorYang, Ji Hun-
dc.contributor.authorChung, Seok-
dc.contributor.authorKim, Sung-Han-
dc.contributor.authorKim, Yeon-Sook-
dc.contributor.authorEui-Cheol Shin-
dc.date.accessioned2023-10-18T22:03:19Z-
dc.date.available2023-10-18T22:03:19Z-
dc.date.created2023-04-03-
dc.date.issued2023-03-
dc.identifier.issn1226-3613-
dc.identifier.urihttps://pr.ibs.re.kr/handle/8788114/14006-
dc.description.abstractWe do not yet understand exactly how corticosteroids attenuate hyperinflammatory responses and alleviate high-risk coronavirus disease 2019 (COVID-19). We aimed to reveal the molecular mechanisms of hyperinflammation in COVID-19 and the anti-inflammatory effects of corticosteroids in patients with high-risk COVID-19. We performed single-cell RNA sequencing of peripheral blood mononuclear cells (PBMCs) from three independent COVID-19 cohorts: cohort 1 was used for comparative analysis of high-risk and low-risk COVID-19 (47 PBMC samples from 28 patients), cohort 2 for longitudinal analysis during COVID-19 (57 PBMC samples from 15 patients), and cohort 3 for investigating the effects of corticosteroid treatment in patients with high-risk COVID-19 (55 PBMC samples from 13 patients). PBMC samples from healthy donors (12 PBMC samples from 12 donors) were also included. Cohort 1 revealed a significant increase in the proportion of monocytes expressing the long noncoding RNAs NEAT1 and MALAT1 in high-risk patients. Cohort 2 showed that genes encoding inflammatory chemokines and their receptors were upregulated during aggravation, whereas genes related to angiogenesis were upregulated during improvement. Cohort 3 demonstrated downregulation of interferon-stimulated genes (ISGs), including STAT1, in monocytes after corticosteroid treatment. In particular, unphosphorylated STAT-dependent ISGs enriched in monocytes from lupus patients were selectively downregulated by corticosteroid treatment in patients with high-risk COVID-19. Corticosteroid treatment suppresses pathologic interferon responses in monocytes by downregulating STAT1 in patients with high-risk COVID-19. Our study provides insights into the mechanisms underlying COVID-19 aggravation and improvement and the effects of corticosteroid treatment. © 2023, The Author(s).-
dc.language영어-
dc.publisher생화학분자생물학회-
dc.titleCorticosteroids reduce pathologic interferon responses by downregulating STAT1 in patients with high-risk COVID-19-
dc.typeArticle-
dc.type.rimsART-
dc.identifier.wosid000953661800001-
dc.identifier.scopusid2-s2.0-85150498346-
dc.identifier.rimsid80434-
dc.contributor.affiliatedAuthorEui-Cheol Shin-
dc.identifier.doi10.1038/s12276-023-00964-8-
dc.identifier.bibliographicCitationExperimental & Molecular Medicine, v.55, no.3, pp.653 - 664-
dc.relation.isPartOfExperimental & Molecular Medicine-
dc.citation.titleExperimental & Molecular Medicine-
dc.citation.volume55-
dc.citation.number3-
dc.citation.startPage653-
dc.citation.endPage664-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.description.journalClass1-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.description.journalRegisteredClasskci-
dc.relation.journalResearchAreaBiochemistry & Molecular Biology-
dc.relation.journalResearchAreaResearch & Experimental Medicine-
dc.relation.journalWebOfScienceCategoryBiochemistry & Molecular Biology-
dc.relation.journalWebOfScienceCategoryMedicine, Research & Experimental-
dc.subject.keywordPlusI INTERFERONS-
dc.subject.keywordPlusMECHANISMS-
dc.subject.keywordPlusIMMUNITY-
Appears in Collections:
Korea Virus Research Institute(한국바이러스기초연구소) > Center for Viral Immunology(바이러스 면역 연구센터) > 1. Journal Papers (저널논문)
Files in This Item:
There are no files associated with this item.

qrcode

  • facebook

    twitter

  • Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse