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Multifunctional porous microspheres encapsulating oncolytic bacterial spores and their potential for cancer immunotherapy

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Title
Multifunctional porous microspheres encapsulating oncolytic bacterial spores and their potential for cancer immunotherapy
Author(s)
Bae, G.-H.; Ryu, Y.-H.; Han, J.; Kim, S.H.; Chun Gwon Park; Park, J.-H.; Kim, D.-H.; Chon, H.J.; Kim, C.; Choi, S.-W.; Park, W.
Publication Date
2023-06
Journal
Biomaterials Science, v.11, no.13, pp.4652 - 4663
Publisher
Royal Society of Chemistry
Abstract
Clostridium novyi-NT (C. novyi-NT) is an anaerobic bacterium that can be used for targeted cancer therapy because it germinates selectively in the hypoxic regions of tumor tissues. However, systemic administration of C. novyi-NT spores cannot effectively treat tumors because of the limited intratumoral delivery of active spores. In this study, we demonstrated that multifunctional porous microspheres (MPMs) containing C. novyi-NT spores have the potential for image-guided local tumor therapy. The MPMs can be repositioned under an external magnetic field, enabling precise tumor targeting and retention. Polylactic acid-based MPMs were prepared using the oil-in-water emulsion technique and then coated with a cationic polyethyleneimine polymer prior to loading with negatively charged C. novyi-NT spores. The C. novyi-NT spores delivered by MPMs were released and germinated in a simulated tumor microenvironment, effectively secreting proteins cytotoxic to tumor cells. In addition, the germinated C. novyi-NT induced immunogenic death of the tumor cells and M1 polarization of macrophages. These results indicate that MPMs encapsulated with C. novyi-NT spores have great potential for image-guided cancer immunotherapy. © 2023 The Royal Society of Chemistry.
URI
https://pr.ibs.re.kr/handle/8788114/13561
DOI
10.1039/d3bm00635b
ISSN
2047-4830
Appears in Collections:
Center for Neuroscience Imaging Research (뇌과학 이미징 연구단) > 1. Journal Papers (저널논문)
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