The adhesion protein IgSF9b is coupled to neuroligin 2 via S-SCAM to promote inhibitory synapse development

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Title
The adhesion protein IgSF9b is coupled to neuroligin 2 via S-SCAM to promote inhibitory synapse development
Author(s)
Jooyeon Woo; Seok-Kyu Kwon; Jungyong Nam; Seungwon Choi; Hideto Takahashi; Dilja Krueger; Joohyun Park; Yeun Kum Lee; Jin Young Bae; Dongmin Lee; Jaewon Ko; Hyun Kim; Myoung-Hwan Kim; Yong Chul Bae; Sunghoe Chang; Ann Marie Craig; Eunjoon Kim
Publication Date
2013-06
Journal
JOURNAL OF CELL BIOLOGY, v.201, no.6, pp.929 - 944
Publisher
ROCKEFELLER UNIV PRESS
Abstract
Synaptic adhesion molecules regulate diverse aspects of synapse formation and maintenance. Many known synaptic adhesion molecules localize at excitatory synapses, whereas relatively little is known about inhibitory synaptic adhesion molecules. Here we report that IgSF9b is a novel, brain-specific, homophilic adhesion molecule that is strongly expressed in GABAergic interneurons. IgSF9b was preferentially localized at inhibitory synapses in cultured rat hippocampal and cortical interneurons and was required for the development of inhibitory synapses onto interneurons. IgSF9b formed a subsynaptic domain distinct from the GABA(A) receptor- and gephyrin-containing domain, as indicated by super-resolution imaging. IgSF9b was linked to neuroligin 2, an inhibitory synaptic adhesion molecule coupled to gephyrin, via the multi-PDZ protein S-SCAM. IgSF9b and neuroligin 2 could reciprocally cluster each other. These results suggest a novel mode of inhibitory synaptic organization in which two subsynaptic domains, one containing IgSF9b for synaptic adhesion and the other containing gephyrin and GABA(A) receptors for synaptic transmission, are interconnected through S-SCAM and neuroligin 2.
URI
https://pr.ibs.re.kr/handle/8788114/1311
ISSN
0021-9525
Appears in Collections:
Center for Synaptic Brain Dysfunctions(시냅스 뇌질환 연구단) > Journal Papers (저널논문)
Files in This Item:
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