IBS Publications Repository: Presynaptic proteoglycans: Sweet organizers of synapse development

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Presynaptic proteoglycans: Sweet organizers of synapse development

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Subject: AMPA receptor, ; glycosylphosphatidylinositol anchored protein, ; glypican, ; glypican 4, ; glypican 6, ; leucine, ; leucine rich repeat transmembrane neuronal 1 protein, ; leucine rich repeat transmembrane neuronal 2 protein, ; leucine rich repeat transmembrane neuronal 4 protein, ; membrane protein, ; neurexin, ; proteoheparan sulfate, ; unclassified drug, ; cell differentiation, ; dentate gyrus, ; electroencephalogram, ; enzyme activity, ; enzyme regulation, ; excitatory postsynaptic potential, ; hippocampal CA1 region, ; human, ; long term potentiation, ; nerve cell differentiation, ; nonhuman, ; presynaptic nerve, ; priority journal, ; protein expression, ; protein function, ; protein protein interaction, ; short survey, ; synapse, ; synaptic transmission, ; Animals, ; Dentate Gyrus, ; Excitatory Postsynaptic Potentials, ; Female, ; Glypicans, ; Heparan Sulfate Proteoglycans, ; Hippocampus, ; Humans, ; Male, ; Nerve Tissue Proteins, ; Neurons, ; Pregnancy, ; Synapses

Abstract: Synaptic adhesion molecules control neuronal synapse development. In this issue of Neuron, Siddiqui etal. (2013) and de Wit etal. (2013) demonstrate that LRRTM4, a postsynaptic adhesion molecule, trans-synaptically interacts with presynaptic heparan sulfate proteoglycans (HSPGs) to promote synapse development